ArticleProceedings of the National Academy of Sciences of the United States of America2011
MHC genotypes associate with resistance to a frog-killing fungus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
155 citing papers in PubMed, 435 citations in OpenAlex.
- Static Expression of Major Histocompatibility Complex Genes Across Life-Stages, Generations and Tissues in a Songbird.Molecular ecology · 2026Article
- Playing it safe at early life stages: Balancing energy allocations to maximize fitness under seasonal pathogen dynamics.The Journal of animal ecology · 2026Article
- Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage.eLife · 2026Article
- Amphibians After Disease-Induced Declines: Genetic Insights Into Population Recoveries.Molecular ecology · 2026Article
- Genomic Correlates of Disease Recovery in Natural Populations of the Sierra Nevada Yellow-Legged Frog (Rana sierrae).Molecular ecology · 2026Article
- Host Genus and Habitat Use Shape the Distribution ofEcology and evolution · 2026Article
- Host Prior Exposure Augments Gene Expression Heterogeneity of Both Host and Pathogen During In Vivo Infection.Molecular ecology · 2026Article
- Comparing Minimally Lethal Sampling Methods for Genomics in the Eastern Oyster (Ecology and evolution · 2026Article
- Major Histocompatibility Complex Immunogenetic Diversity Differs Substantially Across Sea Turtle Species and Genomic Regions.Genome biology and evolution · 2026Article
- Host prior exposure augments heterogeneity in gene expression in both host and pathogen duringbioRxiv : the preprint server for biology · 2025Article
- Natural recolonization of the amphibian skin bacterial community following disruption by antibiotics.Proceedings. Biological sciences · 2025Article
- Amphibian (Journal of fungi (Basel, Switzerland) · 2025Article
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- Quantifying intraspecific variation in host resistance and tolerance to a lethal pathogen.The Journal of animal ecology · 2025Article
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails.Nature communications · 2024Article
- Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial peptides.Scientific reports · 2024Article
- MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.PLoS neglected tropical diseases · 2024Article
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Body size mediates latitudinal population differences in the response to chytrid fungus infection in two amphibians.Oecologia · 2024Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emerging amphibian disease chytridiomycosis is caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd). Amphibian populations and species differ in susceptibility to Bd, yet we know surprisingly little about the genetic basis of this natural variation. MHC loci encode peptides that initiate acquired immunity in vertebrates, making them likely candidates for determining disease susceptibility. However, MHC genes have never been characterized in the context of chytridiomycosis. Here, we performed experimental Bd infections in laboratory-reared frogs collected from five populations that show natural variation in Bd susceptibility. We found that alleles of an expressed MHC class IIB locus associate with survival following Bd infection. Across populations, MHC heterozygosity was a significant predictor of survival. Within populations, MHC heterozygotes and individuals bearing MHC allele Q had a significantly reduced risk of death, and we detected a significant signal of positive selection along the evolutionary lineage leading to allele Q. Our findings demonstrate that immunogenetic variation affects chytridiomycosis survival under controlled experimental conditions, confirming that host genetic polymorphisms contribute to chytridiomycosis resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.