ArticleProceedings of the National Academy of Sciences of the United States of America2011
Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 112 citations in OpenAlex.
- Microbial quorum sensing signals, symbiosis, secrets and sabotage.Microbiology (Reading, England) · 2026Review
- The atypical quorum sensing system of classicalJournal of bacteriology · 2025Review
- Engineering N-acyl-homoserine lactone-based quorum-sensing circuit for dynamic regulatory control in Saccharomyces cerevisiae.Communications biology · 2025Article
- Self-growth suppression inISME communications · 2025Article
- Self-growth suppression inbioRxiv : the preprint server for biology · 2024Article
- Soybean-mediated suppression of BjaI/BjaRApplied and environmental microbiology · 2024Article
- Globally distributed bacteriophage genomes reveal mechanisms of tripartite phage-bacteria-coral interactions.The ISME journal · 2024Article
- Engineering cellular communication between light-activated synthetic cells and bacteria.Nature chemical biology · 2023Article
- AmBio · 2023Article
- A FadR-Type Regulator Activates the Biodegradation of Polycyclic Aromatic Hydrocarbons by Mediating Quorum Sensing in Croceicoccus naphthovorans Strain PQ-2.Applied and environmental microbiology · 2023Article
- Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides.Scientific reports · 2023Article
- Pseudomonas aeruginosa Quorum Sensing.Advances in experimental medicine and biology · 2022Article
- Structural insights into acyl-ACP selective recognition by the Aeromonas hydrophila AHL synthase AhyI.BMC microbiology · 2021Article
- Controlling Synthetic Cell-Cell Communication.Frontiers in molecular biosciences · 2021Review
- Quorum quenching enzymes and their effects on virulence, biofilm, and microbiomes: a review of recent advances.Expert review of anti-infective therapy · 2020Review
- Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities.ACS chemical biology · 2020Article
- Communication within East Antarctic Soil Bacteria.Applied and environmental microbiology · 2019Article
- Characterization of Rhodopseudomonas palustris population dynamics on tobacco phyllosphere and induction of plant resistance to Tobacco mosaic virus.Microbial biotechnology · 2019Article
- Engineered Orthogonal Quorum Sensing Systems for Synthetic Gene Regulation inFrontiers in bioengineering and biotechnology · 2019Article
- Selection of Appropriate Autoinducer Analogues for the Modulation of Quorum Sensing at the Host-Bacterium Interface.ACS chemical biology · 2018Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Many species of Proteobacteria communicate by using LuxI-LuxR-type quorum-sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals. Most of the known signals are straight-chain fatty acyl-HSLs, and evidence indicates that LuxI homologs prefer fatty acid-acyl carrier protein (ACP) over fatty acyl-CoA as the acyl substrate for signal synthesis. Two related LuxI homologs, RpaI and BtaI from Rhodopseudomonas palustris and photosynthetic stem-nodulating bradyrhizobia, direct production of the aryl-HSLs p-coumaroyl-HSL and cinnamoyl-HSL, respectively. Here we report that BjaI from the soybean symbiont Bradyrhizobium japonicum USDA110 is closely related to RpaI and BtaI and catalyzes the synthesis of isovaleryl-HSL (IV-HSL), a branched-chain fatty acyl-HSL. We show that IV-HSL induces expression of bjaI, and in this way IV-HSL functions like many other acyl-HSL quorum-sensing signals. Purified histidine-tagged BjaI was an IV-HSL synthase, which was active with isovaleryl-CoA but not detectably so with isovaleryl-ACP. This suggests that the RpaI-BtaI-BjaI subfamily of acyl-HSL synthases may use CoA- rather than ACP-linked substrates for acyl-HSL synthesis. The bjaI-linked bjaR(1) gene is involved in the response to IV-HSL, and BjaR(1) is sensitive to IV-HSL at concentrations as low as 10 pM. Low but sufficient levels of IV-HSL (about 5 nM) accumulate in B. japonicum culture fluid. The low levels of IV-HSL synthesis have likely contributed to the fact that the quorum-sensing signal from this bacterium has not been described elsewhere.
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