ArticleThe Journal of biological chemistry2011
Down-regulation of UDP-glucuronic acid biosynthesis leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 146 citations in OpenAlex.
- Dehydrogenase WRD1 regulates plant growth by modulating cell wall formation, ROS homeostasis, and auxin signaling in rice.The Plant journal : for cell and molecular biology · 2026Article
- Genome-Wide Identification, Expression, and Functional Analysis of UDP-Glucose Dehydrogenase Family Genes inGenes · 2026Article
- Multi-omics reveals nitrate-induced oxidative stress and morphogenesis pathways inIMA fungus · 2026Article
- Chromosome-scale genome assembly, carbohydrate metabolism transcriptome atlas, and candidate genes for polysaccharide accumulation inFrontiers in plant science · 2026Article
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- Arabinokinase Limits the Flux of Arabinose Into Nucleotide Sugars to Prevent Toxicity.Plant direct · 2025Article
- Storming the barricades of rhamnogalacturonan-II synthesis and function.The Plant cell · 2025Review
- Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification of the bHLH Transcription Factor Family in Orah Mandarin and the Response ofPlants (Basel, Switzerland) · 2025Article
- Juvenile-related tolerance to papaya sticky disease (PSD): proteomic, ultrastructural, and physiological events.Plant cell reports · 2024Article
- Putative rhamnogalacturonan-II glycosyltransferase identified through callus gene editing which bypasses embryo lethality.Plant physiology · 2024Article
- Rhytidome- and cork-type barks of holm oak, cork oak and their hybrids highlight processes leading to cork formation.BMC plant biology · 2024Article
- Integrated Metabolome and Transcriptome Analysis of Gibberellins Mediated the Circadian Rhythm of Leaf Elongation by Regulating Lignin Synthesis in Maize.International journal of molecular sciences · 2024Article
- Organ-specific expression of genes associated with the UDP-glucose metabolism in sugarcane (Saccharum spp. hybrids).BMC genomics · 2023Article
- Genetic dissection reveals the complex architecture of amino acid composition in soybean seeds.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Pectin Characteristics Affect Root Growth in Spinach under Salinity.Plants (Basel, Switzerland) · 2022Article
- Physiological and protein profiling analysis provides insight into the underlying molecular mechanism of potato tuber development regulated by jasmonic acid in vitro.BMC plant biology · 2022Article
- Potential of engineering the myo-inositol oxidation pathway to increase stress resilience in plants.Molecular biology reports · 2022Review
- The regulatory role of CARBON STARVED ANTHER-mediated photoperiod-dependent male fertility in rice.Plant physiology · 2022Article
- Cell Wall Components and Extensibility Regulate Root Growth inPlants (Basel, Switzerland) · 2022Article
12 more citing papers are in PubMed but not listed here.
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8 authors at 3 institutions in 2 countries.
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Abstract
UDP-glucose dehydrogenase (UGD) plays a key role in the nucleotide sugar biosynthetic pathway, as its product UDP-glucuronic acid is the common precursor for arabinose, xylose, galacturonic acid, and apiose residues found in the cell wall. In this study we characterize an Arabidopsis thaliana double mutant ugd2,3 that lacks two of the four UGD isoforms. This mutant was obtained from a cross of ugd2 and ugd3 single mutants, which do not show phenotypical differences compared with the WT. In contrast, ugd2,3 has a strong dwarfed phenotype and often develops seedlings with severe root defects suggesting that the UGD2 and UGD3 isoforms act in concert. Differences in its cell wall composition in comparison to the WT were determined using biochemical methods indicating a significant reduction in arabinose, xylose, apiose, and galacturonic acid residues. Xyloglucan is less substituted with xylose, and pectins have a reduced amount of arabinan side chains. In particular, the amount of the apiose containing side chains A and B of rhamnogalacturonan II is strongly reduced, resulting in a swollen cell wall. The alternative pathway to UDP-glucuronic acid with the key enzyme myo-inositol oxygenase is not up-regulated in ugd2,3. The pathway also does not complement the ugd2,3 mutation, likely because the supply of myo-inositol is limited. Taken together, the presented data underline the importance of UDP GlcA for plant primary cell wall formation.
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