ArticleJournal of the American Society of Nephrology : JASN2011
Glcci1 deficiency leads to proteinuria.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside.Journal of molecular histology · 2024Article
- Kif21a deficiency leads to impaired glomerular filtration barrier function.Scientific reports · 2023Article
- Novel GLCCI1-BRAF fusion drives kinase signaling in a case of pheochromocytomatosis.European journal of endocrinology · 2022Review
- Reduced α-galactosidase A activity in zebrafish (Molecular genetics and metabolism reports · 2022Article
- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research.Laboratory animal research · 2021Review
- Indirect podocyte injury manifested in a partial podocytectomy mouse model.American journal of physiology. Renal physiology · 2021Article
- Prediction of steroid resistance and steroid dependence in nephrotic syndrome children.Journal of translational medicine · 2021Article
- Effects of miR-151-3p-mediated GLCCl1 expression on biological function in children with nephrotic syndrome.American journal of translational research · 2021Article
- MicroRNAs from Extracellular Vesicles Secreted by Bovine Embryos as Early Biomarkers of Developmental Competence.International journal of molecular sciences · 2020Article
- Effects of Glucocorticoid-Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice.Chinese medical journal · 2018Article
- Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes.Experimental & molecular medicine · 2016Article
- Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome.International journal of nephrology · 2016Article
- Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.Developmental cell · 2015Article
- Defining nephrotic syndrome from an integrative genomics perspective.Pediatric nephrology (Berlin, Germany) · 2015Review
- Article
- Using zebrafish to study podocyte genesis during kidney development and regeneration.Genesis (New York, N.Y. : 2000) · 2014Review
- Molecular Mechanisms of Podocyte Development Revealed by Zebrafish Kidney Research.Cell & developmental biology · 2014Article
- "Zebrafishing" for novel genes relevant to the glomerular filtration barrier.BioMed research international · 2013Review
- Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.PloS one · 2013Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unbiased transcriptome profiling and functional genomics approaches identified glucocorticoid-induced transcript 1 (GLCCI1) as being a transcript highly specific for the glomerulus, but its role in glomerular development and disease is unknown. Here, we report that mouse glomeruli express far greater amounts of Glcci1 protein compared with the rest of the kidney. RT-PCR and Western blotting demonstrated that mouse glomerular Glcci1 is approximately 60 kD and localizes to the cytoplasm of podocytes in mature glomeruli. In the fetal kidney, intense Glcci1 expression occurs at the capillary-loop stage of glomerular development. Using gene knockdown in zebrafish with morpholinos, morphants lacking Glcci1 function had collapsed glomeruli with foot-process effacement. Permeability studies of the glomerular filtration barrier in these zebrafish morphants demonstrated a disruption of the selective glomerular permeability filter. Taken together, these data suggest that Glcci1 promotes the normal development and maintenance of podocyte structure and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.