ArticleJournal of immunology (Baltimore, Md. : 1950)2011
B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions.Frontiers in cell and developmental biology · 2022Review
- Altered peripheral B lymphocyte homeostasis and functions mediated by IL-27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis.Clinical and experimental immunology · 2021Article
- Trauma induces expansion and activation of a memory-like Treg population.Journal of leukocyte biology · 2021Article
- The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity toFrontiers in immunology · 2020Article
- B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.mBio · 2017Article
- Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases.Journal of clinical medicine · 2017Review
- Impact of Immune-Modulatory Drugs on Regulatory T Cell.Transplantation · 2016Review
- What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2015Article
- B cells expressing IFN-γ suppress Treg-cell differentiation and promote autoimmune experimental arthritis.European journal of immunology · 2015Article
- Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.Immunology · 2015Article
- Characterization of the B cell response to Leishmania infection after anti-CD20 B cell depletion.International journal of clinical and experimental pathology · 2015Article
- Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis.Expert review of clinical immunology · 2014Review
- Of mice and men: how animal models advance our understanding of T-cell function in RA.Nature reviews. Rheumatology · 2014Review
- CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy.Clinical and experimental immunology · 2014Article
- Treg cells in rheumatoid arthritis: an update.Current rheumatology reports · 2013Review
- Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice.Immunology · 2013Article
- BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia.PloS one · 2013Article
- To B or not to B the conductor of rheumatoid arthritis orchestra.Clinical reviews in allergy & immunology · 2012Review
- B cells as effectors and regulators of sex-biased arthritis.Autoimmunity · 2012Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The efficacy of B cell-depletion therapy in rheumatoid arthritis has driven interest in understanding the mechanism. Because the decrease in autoantibodies in rheumatoid arthritis does not necessarily correlate with clinical outcome, other mechanisms may be operative. We previously reported that in proteoglycan-induced arthritis (PGIA), B cell-depletion inhibits autoreactive T cell responses. Recent studies in B cell-depletion therapy also indicate a role for B cells in suppressing regulatory mechanisms. In this study, we demonstrate that B cells inhibited both the expansion and function of T regulatory (Treg) cells in PGIA. Using an anti-CD20 mAb, we depleted B cells from mice with PGIA and assessed the Treg cell population. Compared to control Ab-treated mice, Treg cell percentages were elevated in B cell-depleted mice, with a higher proportion of CD4(+) T cells expressing Foxp3 and CD25. On a per-cell basis, CD4(+)CD25(+) cells from B cell-depleted mice expressed increased amounts of Foxp3 and were significantly more suppressive than those from control Ab-treated mice. The depletion of Treg cells with an anti-CD25 mAb concurrent with B cell-depletion therapy restored the severity of PGIA to levels equal to untreated mice. Although titers of autoantibodies did not recover to untreated levels, CD4(+) T cell recall responses to the immunizing Ag returned as measured by T cell proliferation and cytokine production. Thus, B cells have the capacity to regulate inflammatory responses by enhancing effector T cells along with suppressing Treg cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.