ReviewCytometry. Part A : the journal of the International Society for Analytical Cytology2011
In vivo photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters.
Review in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comprehensive study on the characterization of lysed blood samples using dual-wavelength photoacoustics.Journal of biomedical optics · 2026Article
- Monitoring Circulating Myeloid Cells in Peritonitis with an In Vivo Imaging Flow Cytometer.Biomolecules · 2024Article
- Study of erythrocyte sedimentation in human blood through the photoacoustic signals analysis.Photoacoustics · 2024Article
- Dynamic modeling of photoacoustic sensor data to classify human blood samples.Medical & biological engineering & computing · 2024Article
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- Optoacoustic Imaging in Inflammation.Biomedicines · 2021Review
- Vascular bifurcation mapping with photoacoustic microscopy.Biomedical optics express · 2020Article
- Photoacoustic and fluorescent effects in multilayer plasmon-dye interfaces.Journal of biophotonics · 2019Article
- Emerging point-of-care technologies for sickle cell disease screening and monitoring.Expert review of medical devices · 2016Review
- Photoacoustic Flow Cytometry for Single Sickle Cell DetectionAnalytical cellular pathology (Amsterdam) · 2016Article
- In vivo cell characteristic extraction and identification by photoacoustic flow cytography.Biomedical optics express · 2015Article
- Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry.Head & neck · 2014Article
- Circulating Tumor Cell Detection and Capture by Photoacoustic Flow Cytometry in Vivo and ex Vivo.Cancers · 2013Article
- Nanotheranostics of circulating tumor cells, infections and other pathological features in vivo.Molecular pharmaceutics · 2013Review
- Photoacoustic flow cytometry.Methods (San Diego, Calif.) · 2012Review
- Noninvasive imaging of flowing blood cells using label-free spectrally encoded flow cytometry.Biomedical optics express · 2012Article
- In vivo flow cytometry: a horizon of opportunities.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2011Review
Corrections and comments
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2 authors.
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Abstract
Alterations of blood rheology (hemorheology) are important for the early diagnosis, prognosis, and prevention of many diseases, including myocardial infarction, stroke, sickle cell anemia, thromboembolism, trauma, inflammation, and malignancy. However, real-time in vivo assessment of multiple hemorheological parameters over long periods of time has not been reported. Here, we review the capabilities of label-free photoacoustic (PA) and photothermal (PT) flow cytometry for dynamic monitoring of hemorhelogical parameters in vivo which we refer to as photoacoustic and photothermal blood rheology. Using phenomenological models, we analyze correlations between both PT and PA signal characteristics in the dynamic modes and following determinants of blood rheology: red blood cell (RBC) aggregation, deformability, shape (e.g., as in sickle cells), intracellular hemoglobin distribution, individual cell velocity, hematocrit, and likely shear rate. We present ex vivo and in vivo experimental verifications involving high-speed PT imaging of RBCs, identification of sickle cells in a mouse model of human sickle cell disease and in vivo monitoring of complex hemorheological changes (e.g., RBC deformability, hematocrit and RBC aggregation). The multi-parameter platform that integrates PT, PA, and conventional optical techniques has potential for translation to clinical applications using safe, portable, laser-based medical devices for point-of-care screening of disease progression and therapy efficiency.
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