Evidence map›Paper›PMID 21948646›Full record

ArticleInvestigative ophthalmology & visual science2011

Rasch analysis of the Ocular Surface Disease Index (OSDI).

Bradley E Dougherty, Jason J Nichols, Kelly K Nichols

2 registry-linked trialsOpen access · hybridAbstract readValidation Study
In one paragraph

Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02148263 nacompletednot on this mapstarted 2014, after this paper: background citation

Contact Lens Adaptation in Neophytes

TypeinterventionalSponsorOhio State UniversityRan2014 to 2019Enrolled25ConditionsContact Lens ComfortArmssenofilcon A
NCT04896658 phase1 / phase2terminatednot on this mapstarted 2021, after this paper: background citation

Belantamab Mafodotin, Cyclophosphamide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2021 to 2024Enrolled10ConditionsRelapsed/Refractory Multiple MyelomaArmsBelantamab Mafodotin, Cyclophosphamide and Dexamethasone
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 164 citations in OpenAlex.

  1. Pooled it
  2. Topical treatments for blepharokeratoconjunctivitis in children.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Systemic treatment for blepharokeratoconjunctivitis in children.The Cochrane database of systematic reviews · 2016
    Pooled it
  4. Trial
  5. Trial
  6. Efficacy and safety of a multi-action tear substitute based on 0.15% cross-linked hyaluronic acid, 3% trehalose and liposomes with stearylamine: A randomized, single-mask, controlled study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bradley E DoughertyThe Ohio State University College of Optometry, Columbus, Ohio, USA.
Jason J Nichols
Kelly K Nichols
University of Houston · USThe Ohio State University · US

Funding

Dry Eye in PostmenopauseR01EY015519 · NEI · UNIVERSITY OF HOUSTON · PI NICHOLS, KELLY K · 2007 to 2011
$1.7M
Interferometric Studies of the Fluid Dynamics of the Tear FilmR01EY017951 · NEI · OHIO STATE UNIVERSITY · PI KING-SMITH, PETER E · 2009 to 2012
$1.2M
Advanced Graduate Training for OptometristsT32EY013359 · NEI · OHIO STATE UNIVERSITY · PI ZADNIK, KARLA · 2001 to 2011
$1.1M
NEI NIH HHS 5T32EY013359NEI NIH HHS EY015519NEI NIH HHS EY017951NEI NIH HHS R01 EY015519NEI NIH HHS R01 EY017951NEI NIH HHS T32 EY013359
6 · The paper itself

Abstract

purposeThe Ocular Surface Disease Index (OSDI) is a 12-item scale for the assessment of symptoms related to dry eye disease and their effect on vision. Its reliability and validity have been investigated within the classical test theory framework and, more recently, using Rasch analysis. The purpose of the present analysis was to more completely investigate the functioning of its response category structure, the validity of its three subscales, and the unidimensionality of the latent construct it is intended to assess.

methodsResponses to the OSDI from 172 females participating in the Dry Eye in Postmenopause (DEiM) study who had previously been diagnosed with dry eye or reported significant ocular irritation and dryness were analyzed. Response category structure and item fit statistics were evaluated for assessment of model fit. Person separation statistics were used to examine the validity of the subscales. Unidimensionality was assessed by principal component analysis (PCA) of model residuals.

resultsThe recommended five-category response structure resulted in disordered response thresholds. A four-category structure resulted in ordered thresholds. Item infit statistics were acceptable for all 12 items. Person separation with this category structure was adequate, with a person separation index of 2.16. None of the three subscales demonstrated adequate person separation. PCA showed one other significant factor onto which the three environmental items loaded significantly.

conclusionsAll items demonstrated acceptable fit to the model after collapsing categories to order the response thresholds. The original subscales did not prove valid, and there is some evidence of multidimensionality and poor targeting.

Indexed as

Severity of Illness IndexAgedDry Eye SyndromesFemaleHumansMiddle AgedModels, StatisticalPostmenopauseReproducibility of ResultsSurveys and QuestionnairesVision, Low

Identifiers

PMID21948646
PMCPMC3230285
OpenAlexW2077724125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.