ArticleMolecular and cellular biochemistry2012
Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth.EMBO reports · 2023Article
- Immunorelated gene polymorphisms associated with acute myeloid leukemia.Clinical and experimental immunology · 2020Article
- STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast cancer risk and clinical outcomes.Medical oncology (Northwood, London, England) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The signal transduction pathways mediating the progress of heart failure have been intensively studied. Altered signaling of the signal transducers and activators of transcription (STATs), which play important roles in regulating cell proliferation, differentiation, and apoptosis, has been observed in the heart. We conducted a pilot study to test whether single nucleotide polymorphisms (SNPs) in STATs were associated with dilated cardiomyopathy (DCM). Genotypes of two SNPs of STATs (rs6503691 C/T in exon 1 of STAT5B and rs4796793 C/G in the 5' region of STAT3) in 251 DCM patients and 484 control subjects were determined with the use of PCR-restriction fragment length polymorphism assay and TaqMan assay, respectively. Significantly increased DCM risk was found to be associated with T allele of rs6503691 (P = 0.012, OR = 1.37, 95% CI = 1.07-1.74). We found that increased DCM risk statistically significantly associated with rs6503691 in a dominant model (P = 0.009, OR = 1.50, 95% CI = 1.11-2.04). No association between DCM risk and rs4796793 was observed (P = 0.706, OR = 1.05, 95% CI = 0.83-1.32). The present pilot study provides evidence that both rs6503691 T allele and CT/TT genotypes, but not rs4796793 C/G in the 5' region of STAT3, are associated with a significantly increased risk of DCM, indicating that common genetic polymorphism in STATs is associated with DCM.
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