ArticleTheory in biosciences = Theorie in den Biowissenschaften2012
Tunable kinetic proofreading in a model with molecular frustration.
Article in Theory in biosciences = Theorie in den Biowissenschaften, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- Can the Immune System Perform a t-Test?PloS one · 2017Article
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Authors and funding
3 authors.
Funding
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Abstract
In complex systems, feedback loops can build intricate emergent phenomena, so that a description of the whole system cannot be easily derived from the properties of the individual parts. Here, we propose that inter-molecular frustration mechanisms can provide non-trivial feedback loops which can develop non-trivial specificity amplification. We show that this mechanism can be seen as a more general form of a kinetic proofreading (KP) mechanism, with an interesting new property, namely the ability to tune the specificity amplification by changing the reactants concentrations. This contrasts with the classical KP mechanism in which specificity is a function of only the reaction rate constants involved in a chemical pathway. These results are also interesting because they show that a wide class of frustration models exists that share the same underlining KP mechanisms, with even richer properties. These models can find applications in different areas such as evolutionary biology, immunology, and biochemistry.
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Registered trials
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