Evidence map›Paper›PMID 21947876›Full record

ReviewCurrent gastroenterology reports2011

Diagnosis and management of pernicious anemia.

Bruno Annibale, Edith Lahner, Gianfranco Delle Fave

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Cobalamin Deficiency in the Elderly.Mediterranean journal of hematology and infectious diseases · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Autoimmune gastritis.Wiener medizinische Wochenschrift (1946) · 2016
    Review
  16. Review
  17. Autoimmune atrophic gastritis--pathogenesis, pathology and management.Nature reviews. Gastroenterology & hepatology · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bruno AnnibaleDepartment of Digestive and Liver Disease, University Sapienza, Medical School, Ospedale Sant'Andrea, Via di Grottarossa 1035, 00189 Rome, Italy. bruno.annibale@uniroma1.it
Edith Lahner
Gianfranco Delle Fave
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of fasting gastrin and decreased levels of Pepsinogen I. Without the now obsolete Schilling's test, intrinsic factor deficiency may not be proven, and gastric intrinsic factor output after pentagastric stimulation has been proposed. Intrinsic factor autoantibodies are useful surrogate markers of pernicious anemia. The management of patients with pernicious anemia should focus on the life-long replacement treatment with cobalamin and the monitoring to early diagnose an eventual onset of iron deficiency. Moreover, these patients should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids.

Indexed as

AchlorhydriaAnemia, PerniciousCarcinoid TumorHumansStomach NeoplasmsVitamin B 12Vitamin B 12 DeficiencyVitamin B 12

Identifiers

PMID21947876
OpenAlexW2029827160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.