ReviewCurrent diabetes reports2011
A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research.
Review in Current diabetes reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.Nature genetics · 2014Pooled it
- Trial
- Circular RNAs and the regulation of gene expression in diabetic nephropathy (Review).International journal of molecular medicine · 2024Article
- Predictive model for aminoglycoside induced ototoxicity.Frontiers in neurology · 2024Article
- Article
- Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.BioMed research international · 2018Review
- Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.Journal of Korean medical science · 2015Article
- Article
- Review
- The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort.PloS one · 2014Article
- Article
- Estimating the predictive ability of genetic risk models in simulated data based on published results from genome-wide association studies.Frontiers in genetics · 2014Article
- Personalized medicine in Type 2 Diabetes.BioMedicine · 2014Article
- Addition of host genetic variants in a prediction rule for post meningitis hearing loss in childhood: a model updating study.BMC infectious diseases · 2013Article
- Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis.Arthritis care & research · 2013Article
- How can polygenic inheritance be used in population screening for common diseases?Genetics in medicine : official journal of the American College of Medical Genetics · 2013Review
- Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction.Deutsches Arzteblatt international · 2013Review
- The value of genetic information for diabetes risk prediction - differences according to sex, age, family history and obesity.PloS one · 2013Article
- Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) study.Diabetes care · 2013Article
- The genetic and epigenetic basis of type 2 diabetes and obesity.Clinical pharmacology and therapeutics · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fueled by the successes of genome-wide association studies, numerous studies have investigated the predictive ability of genetic risk models in type 2 diabetes. In this paper, we review these studies from a methodological perspective, focusing on the variables included in the risk models as well as the study designs and populations investigated. We argue and show that differences in study design and characteristics of the study population have an impact on the observed predictive ability of risk models. This observation emphasizes that genetic risk prediction studies should be conducted in those populations in which the prediction models will ultimately be applied, if proven useful. Of all genetic risk prediction studies to date, only a few were conducted in populations that might be relevant for targeting preventive interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.