SynthesisMolecular biology reports2012
Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 14 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 14 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Association between Susceptibility to Systemic Lupus Erythematous and Polymorphisms in miR-146a and miR-499: A Meta-Analysis.International archives of allergy and immunology · 2023Pooled it
- The association between susceptibility to inflammatory arthritis and miR-146a, miR-499 and IRAK1 polymorphisms. A meta-analysis.Zeitschrift fur Rheumatologie · 2015Pooled it
- The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis : a meta-analysis.Zeitschrift fur Rheumatologie · 2015Pooled it
- Association study of two inflammation-related polymorphisms with susceptibility to hepatocellular carcinoma: a meta-analysis.BMC medical genetics · 2014Pooled it
- Ethnicity modifies the association between functional microRNA polymorphisms and breast cancer risk: a HuGE meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis.Molecular biology reports · 2013Pooled it
- Pooled it
- Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.PloS one · 2013Pooled it
- The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility.PloS one · 2013Pooled it
- The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population.PloS one · 2013Pooled it
- Lack of association of miR-146a rs2910164 polymorphism with gastrointestinal cancers: evidence from 10206 subjects.PloS one · 2012Pooled it
- Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies.PloS one · 2012Pooled it
- Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk.PloS one · 2012Pooled it
- Pooled it
- Article
- Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8.PLoS neglected tropical diseases · 2021Article
- Associations of Single Nucleotide Polymorphism in miR-146a Gene with Susceptibility to Breast Cancer in the Iranian Female.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- An Updated Meta-Analysis of the Associations Between MicroRNA Polymorphisms and Susceptibility to Rheumatoid Arthritis.Frontiers in physiology · 2018Article
- MicroRNA gene polymorphisms and the risk of colorectal cancer.Oncology letters · 2017Article
- Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis.Journal of thoracic disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have evaluated the association between has-miR-146a polymorphism (rs2910164) and cancer risk. However, published data are still inconclusive. Here, we performed a meta-analysis to assess the relationship between has-miR-146a polymorphism (rs2910164) and cancer susceptibility until May 8, 2010. Nineteen published case-control studies including a total of 10,496 cases and 12,885 controls were acquired. Overall, Increased cancer risk was found in domain model (OR = 1.18, 95% CI: 1.03-1.35) rather than in other genetic models when all studies were pooled into the meta-analysis. Stratified analysis shown that significant association between rs2910164 polymorphism and cancer susceptibility was present in Asians (OR = 1.14, 95% CI: 1.01-1.29 for CG vs. CC; OR = 1.19, 95% CI: 1.03-1.39 for GG + CG vs. CC), but not in Caucasian populations. In the subgroup analysis by cancer types, no significantly increased risk of breast, gastric, prostate or bladder cancer were found in any of the genetic models. In summary, this meta-analysis suggests that has-miR-146a polymorphism (rs2910164) is associated with increased cancer susceptibility in Asians. However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.