ArticleImmunogenetics2012
Signatures of historical demography and pathogen richness on MHC class I genes.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Heterogeneity in disease resistance and the impact of antibiotics in the US.Economics and human biology · 2022Article
- Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health.The journal of allergy and clinical immunology. In practice · 2022Article
- Like Wings of a Bird: Functional Divergence and Complementarity between HLA-A and HLA-B Molecules.Molecular biology and evolution · 2021Article
- Article
- Population Genetics and Natural Selection in Rheumatic Disease.Rheumatic diseases clinics of North America · 2017Review
- Influence of HLA on human partnership and sexual satisfaction.Scientific reports · 2016Article
- HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection.Immunogenetics · 2016Article
- Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people.BMC genetics · 2016Article
- HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms.Immunogenetics · 2015Article
- Genetics of autoimmune diseases: insights from population genetics.Journal of human genetics · 2015Review
- Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response.The Journal of allergy and clinical immunology · 2015Review
- Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.PLoS neglected tropical diseases · 2014Article
- HLA variation reveals genetic continuity rather than population group structure in East Asia.Immunogenetics · 2014Article
- Genes associated with SLE are targets of recent positive selection.Autoimmune diseases · 2014Review
- Gene expression drives local adaptation in humans.Genome research · 2013Article
- Common risk alleles for inflammatory diseases are targets of recent positive selection.American journal of human genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The extreme polymorphism of MHC class I has been argued to be driven by balancing selection from pathogens, with the prediction that populations exposed to a wider variety of diseases should have higher diversity. We assembled a global database of allotype frequencies for MHC class I genes and investigated possible drivers of genetic diversity, measured in different ways. We first looked for a decline in diversity with distance from Africa (a consequence of drift during human expansions) and then investigated the link with pathogen richness once the effect of drift had been corrected for. Using heterozygosity, we recovered a clear decline in diversity from Africa and confirmed the positive relationship between genetic diversity and pathogen richness for all three classical MHC class I genes. However, when we considered a sequence-based measure of genetic diversity, the correlation with geographic distance from Africa vanished for HLA-C, and the correlations with pathogen richness for the three MHC class I genes were much weaker. HLA-C is known to consist of two functional classes of allotypes (classified with respect to the 80th residue), which interact with different KIR receptors. While this separation provided some improvement in the fit between genetic diversity and distance from Africa for one class, much clearer and consistent patterns were recovered when we used the 90th residue to separate HLA-C allotypes into two new classes. This suggests that this residue, which is also involved in the binding of KIR, might have had an important evolutionary role that has been overlooked.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.