ArticleImmunogenetics2012
The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Research Progress on the Major Histocompatibility Complex in Herbivores: Structure, Genetics, and Disease Resistance.Biology · 2026Review
- First-time description of MHC diversity in Straight Egyptian Arabian horses using immune-linked microsatellite markers.Frontiers in immunology · 2026Article
- Early allergen introduction overrides allergy predisposition in offspring of horses withFrontiers in immunology · 2025Article
- High-Resolution Genotyping of Expressed Equine MHC Reveals a Highly Complex MHC Structure.Genes · 2023Article
- Association of inbreeding and regional equine leucocyte antigen homozygosity with the prevalence of insect bite hypersensitivity in Old Kladruber horse.Animal genetics · 2021Article
- Inter- and intrabreed diversity of the major histocompatibility complex (MHC) in primitive and draft horse breeds.PloS one · 2020Article
- Article
- MHC haplotype diversity in Icelandic horses determined by polymorphic microsatellites.Genes and immunity · 2019Article
- Article
- Copy number variations in Friesian horses and genetic risk factors for insect bite hypersensitivity.BMC genetics · 2018Article
- MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites.Immunogenetics · 2018Article
- Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology.Scientific reports · 2017Article
- Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.Immunogenetics · 2017Article
- Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH).PloS one · 2016Article
- Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet Diarrhea in Large White, Landrace and Duroc.Asian-Australasian journal of animal sciences · 2013Article
- Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses.Molecular biology reports · 2013Article
- Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands.Genetics, selection, evolution : GSE · 2012Article
- Development of MHC-Linked Microsatellite Markers in the Domestic Cat and Their Use to Evaluate MHC Diversity in Domestic Cats, Cheetahs, and Gir Lions.The Journal of heredityArticle
Corrections and comments
- Erratum issuedSwinbune, June E [corrected to Swinburne, June E]
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within the MHC class II region and sequenced the highly polymorphic exons two from DRA and DRB3, respectively. Initially, 94 IBH-affected and 93 unaffected Swedish born Icelandic horses were tested for genetic association. These horses had previously been genotyped on the Illumina Equine SNP50 BeadChip, which made it possible to ensure that our study did not suffer from the effects of stratification. The second population consisted of 106 unaffected and 80 IBH-affected Exmoor ponies. We show that variants in the MHC class II region are associated with disease susceptibility (p (raw) = 2.34 × 10(-5)), with the same allele (COR112:274) associated in two separate populations. In addition, we combined microsatellite and sequencing data in order to investigate the pattern of homozygosity and show that homozygosity across the entire MHC class II region is associated with a higher risk of developing IBH (p = 0.0013). To our knowledge this is the first time in any atopic dermatitis suffering species, including man, where the same risk allele has been identified in two distinct populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.