ArticleEuropean journal of applied physiology2012
Contractile function and sarcolemmal permeability after acute low-load resistance exercise with blood flow restriction.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Pooled it
- Acute Inflammatory Responses to Blood Flow Restriction Training: A Systematic Review.Sports medicine - open · 2025Pooled it
- Acute and Chronic Effects of Blood Flow Restricted High-Intensity Interval Training: A Systematic Review.Sports medicine - open · 2022Pooled it
- Effect of resistance training with blood flow restriction on muscle damage markers in adults: A systematic review.PloS one · 2021Pooled it
- Effects of different arterial occlusion pressures during blood flow restriction exercise on muscle damage: a single-blind randomized controlled trial.Scientific reports · 2025Trial
- Blood flow restricted training leads to myocellular macrophage infiltration and upregulation of heat shock proteins, but no apparent muscle damage.The Journal of physiology · 2017Trial
- The effect of eccentric exercise with blood flow restriction on neuromuscular activation, microvascular oxygenation, and the repeated bout effect.European journal of applied physiology · 2017Trial
- Blood flow restriction does not result in prolonged decrements in torque.European journal of applied physiology · 2013Trial
- Acute Effects of Low-Load Blood Flow Restriction Exercise on Vastus Lateralis Electromyographic Activity in Healthy Young Adults: A Pilot Randomized Study.Journal of functional morphology and kinesiology · 2026Article
- Blood flow restriction induces similar peripheral stress but greater central drive impairments than systemic hypoxia during repeated cycling sprints.European journal of applied physiology · 2026Article
- Blood flow restriction training: a new approach for preventing and treating sarcopenia in older adults.Frontiers in physiology · 2025Review
- The addition of blood flow restriction during resistance exercise does not increase prolonged low-frequency force depression.Experimental physiology · 2024Article
- Time to consider the potential role of alternative resistance training methods in cancer management?Journal of sport and health science · 2023Review
- Changes in Skeletal Muscle Troponin T and Vitamin D Binding Protein (DBP) Concentrations in the Blood of Male Amateur Athletes Participating in a Marathon and 100 km Adventure Race.International journal of environmental research and public health · 2023Article
- The Acute Impacts of Resistance Training Performed with and without Blood Flow Restriction on Lower Body Muscular Power.International journal of exercise science · 2023Article
- A Comparison between High and Low Cuff Pressures on Muscle Oxygen Saturation and Recovery Responses Following Blood-Flow Restriction Resistance Exercise.Sensors (Basel, Switzerland) · 2022Article
- Hemodynamic Responses to Resistance Exercise with Blood Flow Restriction Using a Practical Method Versus a Traditional Cuff-Inflation System.International journal of environmental research and public health · 2022Article
- Effects of functional electro-stimulation combined with blood flow restriction in affected muscles by spinal cord injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- The effect of acute low-load resistance exercise with the addition of blood flow occlusion on muscle function in boys and men.European journal of applied physiology · 2021Article
- Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflicting findings have been reported regarding muscle damage with low-intensity resistance exercise with blood flow restriction (BFR) by pressure cuffs. This study investigated muscle function and muscle fibre morphology after a single bout of low-intensity resistance exercise with and without BFR. Twelve physically active subjects performed unilateral knee extensions at 30% of their one repetition maximum (1RM), with partial BFR on one leg and the other leg without occlusion. With the BFR leg, five sets were performed to concentric torque failure, and the free-flow leg repeated the exact same number of repetitions and sets. Biopsies were obtained from vastus lateralis before and 1, 24 and 48 h after exercise. Maximum isometric torque (MVC) and resting tension were measured before and after exercise and at 4, 24, 48, 72, 96 and 168 h post-exercise. The results demonstrated significant decrements in MVC (lasting ≥48 h) and delayed onset muscle soreness in both legs, and increased resting tension for the occluded leg both acutely and at 24 h post-exercise. The percentage of muscle fibres showing elevated intracellular staining of the plasma protein tetranectin, a marker for sarcolemmal permeability, was significantly increased from 9% before exercise to 27-38% at 1, 24 and 48 h post-exercise for the BFR leg. The changes in the free-flow leg were significant only at 24 h (19%). We conclude that an acute bout of low-load resistance exercise with BFR resulted in changes suggesting muscle damage, which may have implications both for safety aspects and for the training stimulus with BFR exercise.
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