ArticleAntimicrobial agents and chemotherapy2011
Digallate dimers of (-)-epigallocatechin gallate inactivate herpes simplex virus.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Pyrogallol B-ring enhances catechin binding to the SARS-CoV-2 spike receptor-binding domain to inhibit interaction with ACE2.Scientific reports · 2026Article
- In silico identification of potential phytochemical inhibitors for mpox virus: molecular docking, MD simulation, and ADMET studies.Molecular diversity · 2024Article
- Mechanism of PRRSV infection and antiviral role of polyphenols.Virulence · 2024Review
- Antiviral Effects and Mechanisms of Active Ingredients in Tea.Molecules (Basel, Switzerland) · 2024Review
- Inhibitory effects of algal polysaccharide extract from Cladophora spp. against herpes simplex virus infection.Scientific reports · 2024Article
- Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective.Current research in food science · 2024Review
- Potential of green tea EGCG in neutralizing SARS-CoV-2 Omicron variant with greater tropism toward the upper respiratory tract.Trends in food science & technology · 2023Review
- Adsorption Equilibrium and Thermodynamics of Tea Theasinensins on HP20-A High-Efficiency Macroporous Adsorption Resin.Foods (Basel, Switzerland) · 2021Article
- Natural Products and Their Derivatives against Human Herpesvirus Infection.Molecules (Basel, Switzerland) · 2021Review
- Antiviral Active Compounds Derived from Natural Sources against Herpes Simplex Viruses.Viruses · 2021Review
- Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea VirusFrontiers in pharmacology · 2021Article
- Antimicrobial Activity of Chitosan-Based Films Enriched with Green Tea Extracts on Murine Norovirus,International journal of food science · 2020Article
- Theaflavin-3,3'-Digallate Suppresses Biofilm Formation, Acid Production, and Acid Tolerance inFrontiers in microbiology · 2019Article
- Antiviral Mechanism of Action of Epigallocatechin-3-Molecules (Basel, Switzerland) · 2018Review
- Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice.BMC complementary and alternative medicine · 2018Article
- Anti-infective potential of catechins and their derivatives against viral hepatitis.Clinical and experimental vaccine research · 2018Review
- Evaluation of green tea extract as a safe personal hygiene against viral infections.Journal of biological engineering · 2018Article
- Mechanism of Anti-rotavirus Synergistic Activity by Epigallocatechin Gallate and a Proanthocyanidin-Containing Nutraceutical.Food and environmental virology · 2017Article
- Flavonoids: promising natural compounds against viral infections.Archives of virology · 2017Review
- A Review of the Antiviral Role of Green Tea Catechins.Molecules (Basel, Switzerland) · 2017Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Topical microbicides are potentially an alternative method to vaccines for reducing the spread of herpes simplex virus (HSV). We have previously shown (S. Liu et al., Biochim. Biophys. Acta 1723:270-281, 2005) that the catechin (-)-epigallocatechin gallate (EGCG) inactivates HSV at neutral pH; however, to function in the female genital tract EGCG must also be effective at acidic pH. EGCG inactivated HSV-1 and HSV-2 at pH 8.0 by 3 log(10) to 4 log(10) but was ineffective at pH 5.7. The EGCG digallate dimers theasinensin A, P2, and theaflavin-3,3'-digallate (TF-3) inactivated both viruses by 3 log(10) to 4 log(10) at pH 5.7 and as much as 5 log(10) at pH 8.0. TF-3 inactivated HSV-1 and HSV-2 by 4 to 5 log(10) in the pH range of 4.0 to 5.7. Dimers with one gallate moiety had antiviral activity intermediate between the activities of EGCG and digallate dimers. Confocal and electron microscopy showed that theasinensin A did not damage Vero cells. All EGCG dimers inactivated enveloped viruses with class I, class II, and class III (HSV-1, HSV-2) fusion proteins more effectively than did monomeric EGCG. EGCG had no activity against the nonenveloped viruses tested, but TF-3 reduced the titer of 4 of 5 nonenveloped viruses by ≅2 to 3.5 log(10). Results also showed that HSV-1 glycoprotein B (gB) was aggregated more rapidly by theasinensin A than EGCG, which, when taken together with the nonenveloped virus data, suggests that dimers may inhibit the function of viral proteins required for infectivity. Digallate dimers of EGCG appear to have excellent potential as microbicidal agents against HSV at acidic and neutral pHs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.