Trial reportPsychopharmacology2012
Effects of amphetamine on reactivity to emotional stimuli.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Catecholaminergic modulation of trust decisions.Psychopharmacology · 2019Trial
- Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder.Journal of substance abuse treatment · 2017Trial
- Trial
- Effects of MDMA and Intranasal oxytocin on social and emotional processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans.Psychopharmacology · 2013Trial
- Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior.Psychopharmacology · 2012Trial
- Amping up effort: effects of d-amphetamine on human effort-based decision-making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Trial
- Behavioral Effects of Stimulated Dopamine Release and D2-like Receptor Displacement in Parkinson's Patients with Impulse-Control Disorder.International journal of molecular sciences · 2025Article
- The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects.Npj mental health research · 2024Review
- Deficits in consummatory reward relate to severity of cocaine use.Drug and alcohol dependence · 2023Article
- The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption.Advances in pharmacology (San Diego, Calif.) · 2022Review
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- The Ethics of Motivational Neuro-Doping in Sport: Praiseworthiness and Prizeworthiness.Neuroethics · 2021Article
- Derationalizing Delusions.Clinical psychological science : a journal of the Association for Psychological Science · 2021Review
- Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.Molecular psychiatry · 2020Article
- Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- The Supplement AdulterantThe Journal of pharmacology and experimental therapeutics · 2019Article
- In the face of stress: Interpreting individual differences in stress-induced facial expressions.Neurobiology of stress · 2019Review
- Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults.Cannabis and cannabinoid research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
rationaleMost studies of the reinforcing effects of stimulants have focused on the drugs' capacity to induce positive mood (i.e., euphoria). However, recent findings suggest drugs may also alter emotional reactivity to external stimuli, and that this may occur independently of direct effects on mood.
objectivesWe aimed to examine effects of D: -amphetamine, a prototypic stimulant, on self-reported and psychophysiological reactivity to emotional stimuli as well as overall subjective mood. We predicted that amphetamine would enhance reactivity to pleasant stimuli, particularly, stimuli with social content and that these effects would be independent of the drug's direct effects on mood.
methodsOver three sessions, 36 healthy normal adults received placebo, D: -amphetamine 10 and 20 mg under counterbalanced double-blind conditions. At each session, emotional reactivity to standardized positive, neutral, and negative pictures with and without social content was measured in self-reports and facial muscles sensitive to emotional state. Drug effects on cardiovascular variables and subjective mood were also measured.
resultsAmphetamine produced euphoria, feelings of drug effect, and increased blood pressure. Most notably, amphetamine enhanced self-reported positive reactions to all pictures and psychophysiological reactions to positive pictures. These effects were not significantly related to drug-induced mood changes. Contrary to our hypothesis, effects of amphetamine on emotional reactivity were not moderated by social content.
conclusionsThis study demonstrates a previously unexamined and potentially reinforcing effect of stimulant drugs in humans, distinct from more typically measured euphorigenic effects, and suggests new areas of research in stimulant abuse risk and adaptations occurring during drug dependence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.