ArticlePsychopharmacology2012
Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults.Human psychopharmacology · 2026Trial
- Lithium effects on impulsivity and emotional processing.Scientific reports · 2025Trial
- Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.Psychopharmacology · 2016Trial
- Off-label and investigational drugs in the treatment of gambling disorder: a critical review.Frontiers in pharmacology · 2026Review
- High testosterone levels associated with elevated suicidal risk in male adolescents with depression.BMC psychiatry · 2025Article
- The Potential Use of Ebselen in Treatment-Resistant Depression.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Lithium in drinking water and crime rates in Japan: cross-sectional study.BJPsych open · 2020Article
- Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors.International journal of molecular sciences · 2018Review
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens.Journal of neurochemistry · 2016Article
- The suicide prevention effect of lithium: more than 20 years of evidence-a narrative review.International journal of bipolar disorders · 2015Article
- Acute administration of lithium, but not valproate, modulates cognitive judgment bias in rats.Psychopharmacology · 2015Article
- Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.Translational psychiatry · 2014Review
- Toxins induce 'malaise' behaviour in the honeybee (Apis mellifera).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- The treatment of bipolar patients with elevated impulsivity and suicide risk.Journal of psychiatry & neuroscience : JPN · 2014Article
- Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- NEUROBIOLOGICAL ASPECTS OF SUICIDE AND SUICIDE ATTEMPTS IN BIPOLAR DISORDER.Translational neuroscience · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleHigher impulsivity is a pathological symptom in several psychiatric disorders, including bipolar disorder, and is a risk factor for suicide.
objectivesOur goal was to determine whether major mood-stabilizing drugs used for the treatment of bipolar disorder could suppress impulsive-like action in the three-choice serial reaction time task (3-CSRTT).
methodsFollowing training for the 3-CSRTT, rats were acutely administered lithium chloride (LiCl; 0, 3.2, 10, and 32 mg/kg, i.p.), valproic acid (0, 10, 32, and 100 mg/kg, i.p.), or carbamazepine (0, 10, 20, and 30 mg/kg, i.p.). To assess the anorexic effects of lithium, a simple food consumption test was conducted.
resultsLiCl dose-dependently decreased the number of premature responses, an index of impulsive-like action. A high dose of LiCl (32 mg/kg) decreased food consumption, but its anorexic effects were not correlated with the effects of LiCl on premature responses. A moderate dose of LiCl (20 mg/kg) significantly reduced the number of premature responses without affecting motivation-related measures in the 3-CSRTT or the amount of food consumption. Although carbamazepine prolonged reward latency, an index of motivation for food, neither valproic acid nor carbamazepine significantly affected premature responses.
conclusionIt is likely that lithium has a suppressive effect on impulsive action independent of the anorexic effect. Lithium may suppress impulsive behavior and thereby decrease the risk of suicide. The present results could provide an explanation for the antisuicidal effects of lithium and suggest that lithium could be a beneficial treatment for impulsivity-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.