ArticleMolecular and cellular biology2011
FOSL1 is integral to establishing the maternal-fetal interface.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 72 citations in OpenAlex.
- DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.Clinical epigenetics · 2020Trial
- Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms.Translational psychiatry · 2026Article
- Super-Enhancers in Placental Development and Diseases.Journal of developmental biology · 2025Review
- KLF14 inhibits tumor progression via FOSL1 in glioma.Biochemistry and biophysics reports · 2025Article
- The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation.Development (Cambridge, England) · 2023Article
- MicroRNAs: key regulators of the trophoblast function in pregnancy disorders.Journal of assisted reproduction and genetics · 2023Review
- Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.International journal of molecular sciences · 2022Article
- Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat.International journal of molecular sciences · 2022Review
- Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression.International journal of molecular sciences · 2022Article
- The Fra-1: Novel role in regulating extensive immune cell states and affecting inflammatory diseases.Frontiers in immunology · 2022Review
- FosL1 Is a Novel Target of Levetiracetam for Suppressing the Microglial Inflammatory Reaction.International journal of molecular sciences · 2021Article
- Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.Molecular and cellular biology · 2021Article
- Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling.Placenta · 2021Review
- SUV39H2 controls trophoblast stem cell fate.Biochimica et biophysica acta. General subjects · 2021Article
- SATB1 promotion of trophoblast stem cell renewal through regulation of threonine dehydrogenase.Biochimica et biophysica acta. General subjects · 2021Article
- The expression and biological function of chemokine CXCL12 and receptor CXCR4/CXCR7 in placenta accreta spectrum disorders.Journal of cellular and molecular medicine · 2020Article
- Estrogen-induced FOS-like 1 regulates matrix metalloproteinase expression and the motility of human endometrial and decidual stromal cells.The Journal of biological chemistry · 2020Article
- Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia.International journal of molecular sciences · 2020Article
- Accelerator or Brake: Immune Regulators in Malaria.Frontiers in cellular and infection microbiology · 2020Review
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Remodeling of uterine spiral arteries by trophoblast cells is a requisite process for hemochorial placentation and successful pregnancy. The rat exhibits deep intrauterine trophoblast invasion and accompanying trophoblast-directed vascular modification. The involvement of phosphatidylinositol 3 kinase (PI3K), AKT, and Fos-like antigen 1 (FOSL1) in regulating invasive trophoblast and hemochorial placentation was investigated using Rcho-1 trophoblast stem cells and rat models. Disruption of PI3K/AKT with small-molecule inhibitors interfered with the differentiation-dependent elaboration of a signature invasive-vascular remodeling trophoblast gene expression profile and trophoblast invasion. AKT isoform-specific knockdown also affected the signature invasive-vascular remodeling trophoblast gene expression profile. Nuclear FOSL1 increased during trophoblast cell differentiation in a PI3K/AKT-dependent manner. Knockdown of FOSL1 disrupted the expression of a subset of genes associated with the invasive-vascular remodeling trophoblast phenotype, including the matrix metallopeptidase 9 gene (Mmp9). FOSL1 was shown to occupy regions of the Mmp9 promoter in trophoblast cells critical for the regulation of Mmp9 gene expression. Inhibition of FOSL1 expression also abrogated trophoblast invasion, as assessed in vitro and following in vivo trophoblast-specific lentivirally delivered FOSL1 short hairpin RNA (shRNA). In summary, FOSL1 is a key downstream effector of the PI3K/AKT signaling pathway responsible for development of trophoblast lineages integral to establishing the maternal-fetal interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.