ArticleHuman reproduction (Oxford, England)2011
Fatherhood and the risk of cardiovascular mortality in the NIH-AARP Diet and Health Study.
Article in Human reproduction (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Clinical correlation among male infertility and overall male health: A systematic review of the literature.Investigative and clinical urology · 2020Pooled it
- Associations of Fatherhood and Race With Cardiovascular Health Among Men: Findings From the Coronary Artery Risk Development in Young Adults (CARDIA) Study, 1985‒2022, United States.American journal of public health · 2026Article
- Are infertile men at a higher risk of morbidity and early mortality?Human reproduction (Oxford, England) · 2026Review
- Article
- Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications.Journal of clinical medicine · 2025Review
- Male Fertility as a Proxy for Health.Journal of clinical medicine · 2024Review
- Fatherhood and Cardiovascular Health, Disease, and Mortality: Associations From the Multi-Ethnic Study of Atherosclerosis.AJPM focus · 2024Article
- Child rearing or childbearing? Risk of cardiovascular diseases associated to parity and number of children.BMC public health · 2024Article
- Trends and projections of the burden of disease for male infertility in China from 1990 to 2021: an analysis from the Global Burden of Disease 2021 study.Frontiers in reproductive health · 2024Article
- A novel ADGRG2 truncating variant associated with X-linked obstructive azoospermia in a large Chinese pedigree.Journal of assisted reproduction and genetics · 2023Article
- Echocardiographic and hemodynamic changes in patients with high-grade varicocele.Biomolecules & biomedicine · 2023Article
- Self-reported Male Infertility and Metabolic Disturbance: A Cross-Sectional Study.International journal of endocrinology and metabolism · 2023Article
- Male Infertility Increases the Risk of Cardiovascular Diseases: A Nationwide Population-Based Cohort Study in Taiwan.The world journal of men's health · 2022Article
- Association between Parenthood and Health Behaviour in Later Life-Results from the Population-Based CARLA Study.International journal of environmental research and public health · 2021Article
- Impact of genetic risk score on the association between male childlessness and cardiovascular disease and mortality.Scientific reports · 2021Article
- Male Infertility Knowledgebase: decoding the genetic and disease landscape.Database : the journal of biological databases and curation · 2021Article
- The Association Between Male Infertility and Cardiometabolic Disturbances: A Population-Based Study.International journal of endocrinology and metabolism · 2021Article
- Number of parity/live birth(s) and cardiovascular disease among Iranian women and men: results of over 15 years of follow-up.BMC pregnancy and childbirth · 2021Article
- Consumption of cruciferous vegetables and the risk of bladder cancer in a prospective US cohort: data from the NIH-AARP diet and health study.American journal of clinical and experimental urology · 2021Article
- At-home sperm testing for epidemiologic studies: Evaluation of the Trak male fertility testing system in an internet-based preconception cohort.Paediatric and perinatal epidemiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundFertility potential and reproductive fitness may reflect a man's future health, given that over one-third of the male human genome is involved in reproduction. We sought to determine if offspring number predicts cardiovascular death in the US men.
methodsUsing data from the NIH-AARP Diet and Health Study, 137,903 men (aged 50-71) without prior cardiovascular disease were followed-up for an average of 10.2 years. International Classification of Diseases, ninth edition, codes were used to establish the cause of death, and multivariable Cox proportional hazards modeling was used to estimate the association between offspring number and cardiovascular death while accounting for sociodemographic and lifestyle characteristics.
resultsAlmost all (92%) participants had fathered at least one child and 50% had three or more offspring. A total of 3082 men died of cardiovascular causes during follow-up for an age-adjusted incidence rate of 2.70 per 1000 person-years. Compared with fathers, after adjusting for sociodemographic and lifestyle factors, childless men had a 17% [hazard ratio (HR): 1.17; 95% confidence interval (CI): 1.03-1.32] increased risk of death from cardiovascular disease contracted in the study period, and this elevated risk appeared to extend also to men with only one child. In comparison with fathers of five or more children, adjusted relative hazards for cardiovascular mortality of this sort were 1.06 (95% CI: 0.92-1.22) for four children, 1.02 (0.90-1.16) for three children, 1.02 (0.90-1.16) for two children, 1.11 (0.95-1.30) for one child and 1.21 (1.03-1.41) for no children.
conclusionsMarried men who have no children have a higher risk of dying from cardiovascular disease contracted after the age of 50 than men with two or more children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.