Trial reportThe Journal of physiology2011
Strength training increases the size of the satellite cell pool in type I and II fibres of chronically painful trapezius muscle in females.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta-analysis.Experimental physiology · 2026Pooled it
- Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles.BioMed research international · 2013Trial
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Skeletal Fiber Type in Muscle Pain and Dysfunction.Biomedicines · 2026Review
- Is there a volume saturation point for muscle hypertrophy in resistance-trained individuals? A narrative review.European journal of applied physiology · 2025Review
- Klotho regulates the myogenic response of muscle to mechanical loading and exercise.Experimental physiology · 2023Article
- TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.Journal of cachexia, sarcopenia and muscle · 2023Article
- ApoE isoform does not influence skeletal muscle regeneration in adult mice.Frontiers in physiology · 2023Article
- Sarcopenia: What Is the Origin of This Aging-Induced Disorder?Frontiers in genetics · 2021Review
- Satellite cells in ageing: use it or lose it.Open biology · 2020Review
- mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth.Cells · 2019Article
- Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model.BioMed research international · 2019Article
- Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo.International journal of molecular sciences · 2018Article
- The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis.European journal of applied physiology · 2018Review
- Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men.PloS one · 2018Article
- Exercise is more than medicine: The working age population's well-being and productivity.Journal of sport and health science · 2016Review
- Skeletal Muscle Loading Changes its Regenerative Capacity.Sports medicine (Auckland, N.Z.) · 2016Review
- High Intensity Training May Reverse the Fiber Type Specific Decline in Myogenic Stem Cells in Multiple Sclerosis Patients.Frontiers in physiology · 2016Article
- Satellite cell activity, without expansion, after nonhypertrophic stimuli.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease.Cell death & disease · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While strength training has been shown to be effective in mediating hypertrophy and reducing pain in trapezius myalgia, responses at the cellular level have not previously been studied. This study investigated the potential of strength training targeting the affected muscles (SST, n = 18) and general fitness training (GFT, n = 16) to augment the satellite cell (SC) and macrophage pools in the trapezius muscles of women diagnosed with trapezius myalgia. A group receiving general health information (REF, n = 8) served as a control. Muscle biopsies were collected from the trapezius muscles of the 42 women (age 44 ± 8 years; mean ± SD) before and after the 10 week intervention period and were analysed by immunohistochemistry for SCs, macrophages and myonuclei. The SC content of type I and II fibres was observed to increase significantly from baseline by 65% and 164%, respectively, with SST (P < 0.0001), together with a significant correlation between the baseline number of SCs and the extent of hypertrophy (r = -0.669, P = 0.005). SST also resulted in a 74% enhancement of the trapezius macrophage content (P < 0.01), accompanied by evidence for the presence of an increased number of actively dividing cells (Ki67(+)) post-SST (P < 0.001). GFT resulted in a significant 23% increase in the SC content of type II fibres, when expressed relative to myonuclear number only (P < 0.05). No changes in the number of myonuclei per fibre or myonuclear domain were detected in any group. These findings provide strong support at the cellular level for the potential of SST to induce a strong myogenic response in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.