ArticleNature genetics2011
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
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In one paragraph
Article in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers, 9 of them syntheses that pooled it.
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262citing papers in PubMed, 9 pooled it
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Who cites it
262 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.PloS one · 2022Pooled it
- Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.Thorax · 2021Pooled it
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.Nature communications · 2018Pooled it
- Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.Nature genetics · 2018Pooled it
- Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.American journal of respiratory cell and molecular biology · 2017Pooled it
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Nature genetics · 2016Pooled it
- Pooled it
- Genome-Wide Association Analysis of Single-Breath DlAmerican journal of respiratory cell and molecular biology · 2019Trial
- Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial.American journal of respiratory and critical care medicine · 2019Trial
- Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables.Scientific reports · 2018Trial
- A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.BMC genetics · 2015Trial
- Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.American journal of respiratory and critical care medicine · 2014Trial
- ZKSCAN3 mitigates lipopolysaccharide-induced acute lung injury by restraining excessive autophagy via activation of the mTOR pathway.Journal of thoracic disease · 2026Article
- Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development.American journal of respiratory cell and molecular biology · 2026Article
- Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice.Journal of lipid research · 2026Article
- Regenerative therapeutics for chronic obstructive pulmonary disease.Pharmacological reviews · 2026Review
- Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development.Genomics, proteomics & bioinformatics · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
202 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
171 authors.
María Soler ArtigasDepartment of Health Sciences, University of Leicester, Leicester, UK.
Daan W Loth
Louise V Wain
Sina A Gharib
Ma'en Obeidat
Wenbo Tang
Guangju Zhai
Jing Hua Zhao
Albert Vernon Smith
Jennifer E Huffman
Eva Albrecht
Catherine M Jackson
David M Evans
Gemma Cadby
Myriam Fornage
Ani Manichaikul
Lorna M Lopez
Toby Johnson
Melinda C Aldrich
Thor Aspelund
Inês Barroso
Harry Campbell
Patricia A Cassano
David J Couper
Gudny Eiriksdottir
Nora Franceschini
Melissa Garcia
Christian Gieger
Gauti Kjartan Gislason
Ivica Grkovic
Christopher J Hammond
Dana B Hancock
Tamara B Harris
Adaikalavan Ramasamy
Susan R Heckbert
Markku Heliövaara
Georg Homuth
Pirro G Hysi
Alan L James
Stipan Jankovic
Bonnie R Joubert
Stefan Karrasch
Norman Klopp
Beate Koch
Stephen B Kritchevsky
Lenore J Launer
Yongmei Liu
Laura R Loehr
Kurt Lohman
Ruth J F Loos
Thomas Lumley
Khalid A Al Balushi
Wei Q Ang
R Graham Barr
John Beilby
John D Blakey
Mladen Boban
Vesna Boraska
Jonas Brisman
John R Britton
Guy G Brusselle
Cyrus Cooper
Ivan Curjuric
Santosh Dahgam
Ian J Deary
Shah Ebrahim
Mark Eijgelsheim
Clyde Francks
Darya Gaysina
Raquel Granell
Xiangjun Gu
John L Hankinson
Rebecca Hardy
Sarah E Harris
John Henderson
Amanda Henry
Aroon D Hingorani
Albert Hofman
Patrick G Holt
Jennie Hui
Michael L Hunter
Medea Imboden
Karen A Jameson
Shona M Kerr
Ivana Kolcic
Florian Kronenberg
Jason Z Liu
Jonathan Marchini
Tricia McKeever
Andrew D Morris
Anna-Carin Olin
David J Porteous
Dirkje S Postma
Stephen S Rich
Susan M Ring
Fernando Rivadeneira
Thierry Rochat
Avan Aihie Sayer
Ian Sayers
Peter D Sly
George Davey Smith
Akshay Sood
John M Starr
André G Uitterlinden
Judith M Vonk
S Goya Wannamethee
Peter H Whincup
Cisca Wijmenga
O Dale Williams
Andrew Wong
Massimo Mangino
Kristin D Marciante
Wendy L McArdle
Bernd Meibohm
Alanna C Morrison
Kari E North
Ernst Omenaas
Lyle J Palmer
Kirsi H Pietiläinen
Isabelle Pin
Ozren Pola Sbreve Ek
Anneli Pouta
Bruce M Psaty
Anna-Liisa Hartikainen
Taina Rantanen
Samuli Ripatti
Jerome I Rotter
Igor Rudan
Alicja R Rudnicka
Holger Schulz
So-Youn Shin
Tim D Spector
Ida Surakka
Veronique Vitart
Henry Völzke
Nicholas J Wareham
Nicole M Warrington
H-Erich Wichmann
Sarah H Wild
Jemma B Wilk
Matthias Wjst
Alan F Wright
Lina Zgaga
Tatijana Zemunik
Craig E Pennell
Fredrik Nyberg
Diana Kuh
John W Holloway
H Marike Boezen
Debbie A Lawlor
Richard W Morris
Nicole Probst-Hensch
International Lung Cancer Consortium
GIANT consortium
Jaakko Kaprio
James F Wilson
Caroline Hayward
Mika Kähönen
Joachim Heinrich
Arthur W Musk
Deborah L Jarvis
Sven Gläser
Marjo-Riitta Järvelin
Bruno H Ch Stricker
Paul Elliott
George T O'Connor
David P Strachan
Stephanie J London
Ian P Hall
Vilmundur Gudnason
Martin D Tobin
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MUNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MZUNI KIDNEY PROJECT STUDY I--POPULATION BASED SURVEY OF RENAL DISEASEM01RR000997 · NCRR · UNIVERSITY OF NEW MEXICO · PI ROLDAN, CARLOS A · 1985 to 2010
$30.0MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MMulti-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4MBiotechnology and Biological Sciences Research Council BB/F019394/1Biotechnology and Biological Sciences Research Council G20234British Heart Foundation FS05/125British Heart Foundation PG/06/154/22043British Heart Foundation PG/97012British Heart Foundation RG/08/013/25942Cancer Research UKChief Scientist Office CZB/4/710Chief Scientist Office CZD/16/6Chief Scientist Office CZD/16/6/2Chief Scientist Office CZD/16/6/4CIHR MOP-82893Department of HealthIntramural NIH HHS Z01 ES049019Medical Research Council G0000934Medical Research Council G0401540Medical Research Council G0500539Medical Research Council G0501942Medical Research Council G0600705Medical Research Council G0701863Medical Research Council G0800582Medical Research Council G0801056Medical Research Council G0902125Medical Research Council G0902313Medical Research Council G1000861Medical Research Council G9815508Medical Research Council G9901462Medical Research Council MC_PC_U127561128Medical Research Council MC_U106188470Medical Research Council MC_U123092720Medical Research Council MC_U123092721Medical Research Council MC_U127561128Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015NCI NIH HHS 1P50 CA70907NCI NIH HHS CA127219NCI NIH HHS CA55769NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA111703NCI NIH HHS R01CA111703NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS U19 CA148127NCRR NIH HHS 5M01 RR00997NCRR NIH HHS M01 RR000425NCRR NIH HHS M01 RR000997NCRR NIH HHS M01-RR00425NCRR NIH HHS RR-024156NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01-HG-004402NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01-HG-004729NHLBI NIH HHS 1K23HL094531-01NHLBI NIH HHS 5R01HL087679-02NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS 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Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
Indexed as
Genome-Wide Association StudyRespiratory Function TestsChildHumansPulmonary Disease, Chronic ObstructiveWhite People
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