ArticleBehavioural brain research2012
Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.Biological psychiatry · 2013Trial
- PTH-induced behavioral and metabolic alterations in mouse models of hyperparathyroidism.iScience · 2026Article
- The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice.Journal of neuroinflammation · 2023Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- The impact of the ovarian cycle on anxiety, allopregnanolone, and corticotropin releasing hormone changes after motherhood in female rats and women.Translational psychiatry · 2023Article
- Mouse spontaneous behavior reflects individual variation rather than estrous state.Current biology : CB · 2023Article
- Minimal influence of estrous cycle on studies of female mouse behaviors.Frontiers in molecular neuroscience · 2023Article
- What Pre-clinical Rat Models Can Tell Us About Anxiety Across the Menstrual Cycle in Healthy and Clinically Anxious Humans.Current psychiatry reports · 2022Review
- Preventing Phosphorylation of the GABAFrontiers in molecular neuroscience · 2022Article
- Effect of Estrous Cycle on Behavior of Females in Rodent Tests of Anxiety.Frontiers in psychiatry · 2021Review
- Essential Role of Ovarian Hormones in Susceptibility to the Consequences of Witnessing Social Defeat in Female Rats.Biological psychiatry · 2018Article
- Involvement of Epigenetic Modifications of GABAergic Interneurons in Basolateral Amygdala in Anxiety-like Phenotype of Prenatally Stressed Mice.The international journal of neuropsychopharmacology · 2018Article
- Learning and memory are impaired in the object recognition task during metestrus/diestrus and after sleep deprivation.Behavioural brain research · 2018Article
- Effect of post-weaning isolation on anxiety- and depressive-like behaviors of C57BL/6J mice.Experimental brain research · 2017Article
- Behavior of Male and Female C57BL/6J Mice Is More Consistent with Repeated Trials in the Elevated Zero Maze than in the Elevated Plus Maze.Frontiers in behavioral neuroscience · 2017Article
- Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner.Behavior genetics · 2015Article
- Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene.Behavior genetics · 2015Article
- Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming.Pharmacology, biochemistry, and behavior · 2014Article
- Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS.Hormones and behavior · 2014Article
- Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice.Behavioural brain research · 2013Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
There are estrous cycle differences in affective behaviors of rodents that are generally attributed to cyclic variations in estradiol, progesterone (P) and its metabolites. A question is the role of the steroid metabolism enzyme, 5α-reductase, for these estrous cycle differences. To address the requirement of 5α-reductase, estrous cycle variations in the behavior of wildtype mice and their littermates that are deficient in the 5α-reductase type 1 enzyme (5αRKO mice) were examined. The hypothesis was that if some of the estrous cycle differences in exploratory (open field) and anxiety (elevated plus maze) are due to P's 5α-reduction to 5α-pregnan-3α-ol-20-one (3α,5α-THP), then wildtype mice will have estrous cycle differences in the expression of these behaviors, but 5αRKO mice will not. Mice were tested in these tasks and then had plasma and brains collected so that steroid levels (estradiol, P, 3α,5α-THP, corticosterone) could be measured in these tissues. Results supported this hypothesis. There were estrous cycle differences among wildtype, but not 5αRKO, mice. Proestrous wildtype mice made more central entries in the open field and spent more time on the open arms of the plus maze, coincident with higher 3α,5α-THP levels in plasma and brain regions important for these behaviors, such as the hippocampus and cortex, compared to their diestrous counterparts. Variability in the open field and elevated plus maze could be explained by circulating and hippocampus levels of 3α,5α-THP, respectively. Thus, 5α-reductase may be required for the estrous cycle variations in affective behavior and 3α,5α-THP levels of female mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.