ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011
Comparative long-term adverse effects elicited by invasive group B and C meningococcal infections.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Range of invasive meningococcal disease sequelae and health economic application - a systematic and clinical review.BMC public health · 2022Pooled it
- Invasive meningococcal disease over five decades in the Faroe Islands: high incidence, low mortality, and implications for vaccination policy.IJID regions · 2026Article
- Adverse Events Following Immunization With mRNA and Viral Vector Vaccines in Individuals With Previous Severe Acute Respiratory Syndrome Coronavirus 2 Infection From the Canadian National Vaccine Safety Network.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Care pathways in invasive meningococcal disease: a retrospective analysis of the French national public health insurance database.Human vaccines & immunotherapeutics · 2022Article
- [Journal of preventive medicine and hygiene · 2021Article
- Why the Anti-Meningococcal B Vaccination during Adolescence Should Be Implemented in Italy: An Overview of Available Evidence.Microorganisms · 2020Review
- [Health Technology Assessment of meningococcal B vaccine (TrumenbaJournal of preventive medicine and hygiene · 2019Article
- A DELPHI study on aspects of study design to overcome knowledge gaps on the burden of disease caused by serogroup B invasive meningococcal disease.Health and quality of life outcomes · 2019Article
- The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology.Frontiers in immunology · 2019Review
- Systematic Review of Invasive Meningococcal Disease: Sequelae and Quality of Life Impact on Patients and Their Caregivers.Infectious diseases and therapy · 2018Review
- Acute polyarthritis in a young patient caused by meningococcal and parvovirus B19 infections: a case report and review of the literature.Journal of medical case reports · 2016Review
- Vaccinating Italian infants with a new multicomponent vaccine (Bexsero®) against meningococcal B disease: A cost-effectiveness analysis.Human vaccines & immunotherapeutics · 2016Article
- Unveiling New Aspects of Meningococcal Carriage and Disease Prevention.Journal of clinical microbiology · 2016Article
- Vaccines, adjuvants and autoimmunity.Pharmacological research · 2015Review
- Primary meningococcal polyarthritis in an adult woman.Case reports in medicine · 2015Article
- Health and economic outcomes of introducing the new MenB vaccine (Bexsero) into the Italian routine infant immunisation programme.PloS one · 2015Article
- Cost-effectiveness of vaccination against meningococcal B among Dutch infants: Crucial impact of changes in incidence.Human vaccines & immunotherapeutics · 2013Article
- Controversies in neurology, Vienna, 2012: steroids in bacterial meningitis: no.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- The Long Road to an Effective Vaccine for Meningococcus Group B (MenB).Annals of medicine and surgery (2012) · 2013Review
- Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGiven the identity between Neisseria meningitidis serogroup B (MenB) capsular polysaccharide (polysialic acid; PSA) and PSA found on neural cell adhesion molecules, it has been proposed that infection with MenB or vaccination with PSA may be associated with subsequent autoimmune or neurological disease.
methodsWe conducted 2 studies. The first was a retrospective nationwide study of invasive meningococcal disease (IMD) in Iceland (with 541 subjects) during the period 1975-2004, and we cross referenced this cohort with databases with respect to subsequent diagnosis of autoimmune disorders. A follow-up study involving 120 survivors of IMD was performed. The study included 70 patients with a history of MenB and 50 patients with N. meningitidis serogroup C (MenC) infection, who served as control subjects. Participants answered standardized questionnaires (Beck's Depression Inventory [BDI] II, Depression Anxiety Stress Scales [DASS], and Patient Health Questionnaire [PHQ]), and serum levels of immunoglobulin (Ig) G against MenB and MenC capsular polysaccharides were measured.
resultsThe nationwide cohort had 9166 patient-years of follow up. No evidence of increased autoimmunity was found to be associated with MenB, compared with MenC. In the follow-up study, patients were evaluated 16.6 years after the infection, representing 2022 patient-years of observation. Comparable rates of most complications were recorded, but MenC infections were associated with arthritis (P = .008) and migraine headaches (P = .01) more frequently than were MenB infections. No difference was observed with respect to scores on BDI-II, DASS, or PHQ. IgG anti-MenB and anti-MenC capsular polysaccharide levels were not related to patient complaints.
conclusionsThis study does not support the hypothesis that MenB infection may predispose to autoimmunity. MenC infections are associated with a higher prevalence of arthritis and migraine headaches. No evidence of antibody-associated pathology was detected at long-term follow-up.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.