ArticleJournal of endocrinological investigation2012
The usefulness of high pre-operative levels of serum type I collagen bone markers for the prediction of changes in bone mineral density after parathyroidectomy.
Article in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Novel aspects of biochemical assessment of bone remodeling and mineralization.Frontiers in endocrinology · 2025Review
- 24-hour Urine Calcium Predicts Reduced Fracture Incidence and Improved Bone Mineral Density After Surgery for Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2024Article
- Changes in bone turnover markers and bone mineral density after radiofrequency ablation for mild primary hyperparathyroidism: a prospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- The Use of Bone-Turnover Markers in Asia-Pacific Populations.Annals of laboratory medicine · 2024Review
- Bone Turnover Markers: Basic Biology to Clinical Applications.Endocrine reviews · 2023Article
- Evaluation of preoperative procollagen type 1 N-terminal peptide and collagen type 1 C-telopeptide levels in the prediction of postoperative hypocalcemia in patients undergoing parathyroidectomy due to primary hyperparathyroidism.Langenbeck's archives of surgery · 2023Observational
- Skeletal abnormalities in Hypoparathyroidism and in Primary Hyperparathyroidism.Reviews in endocrine & metabolic disorders · 2021Review
- Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2021Article
- Biochemical bone turnover markers in hormonal disorders in adults: a narrative review.Journal of endocrinological investigation · 2020Review
- Article
- Prediction of bone mass changes after successful parathyroidectomy using biochemical markers of bone metabolism in primary hyperparathyroidism: is it clinically useful?Archives of endocrinology and metabolism · 2019Article
- Skeletal Microstructure and Estimated Bone Strength Improve Following Parathyroidectomy in Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Article
- Bone Turnover Status: Classification Model and Clinical Implications.International journal of medical sciences · 2018Article
- Primary Hyperparathyroidism.F1000Research · 2016Review
- Article
- Bone turnover markers in primary hyperparathyroidism.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmino-terminal procollagen propeptide of type I collagen (P1NP) and cross-linked C-terminal telopeptide of type I collagen (βCTX) are two of the more sensitive bone markers for reflecting and monitoring patients with an increased bone turnover as observed in primary hyperparathyroidism (PHPT) patients.
aimThe present study was performed to evaluate the trend of type I collagen markers one year after parathyroidectomy (PTX) and to examine the relationships between serum P1NP and βCTX levels and bone mineral density (BMD) change after PTX in PHPT Spanish patients. MATERIALS AND
methodsFifty-three PHPT patients were enroled and were followed for one year by measuring lumbar BMD, lumbar t-score, lumbar z-score, PTH, calcium, phosphorus, P1NP and βCTX.
resultsPre-surgery concentrations of both markers were elevated (P1NP: 90.71±5.03; βCTX: 1.52±0.44). A significant decrease was observed in mean post-operative βCTX and P1NP concentrations (p<0.0001). Levels of BMD, t-score and z-score at lumbar spine were relatively low (BMD: 0.75±0.16; z-score -0.90±0.23; t-score -2.51±0.32); after PTX a significant increase was observed in the levels of these three parameters. P1NP and βCTX were correlated with lumbar BMD change one year after PTX (P1NP: r=0.79, p=0.016; βCTX: r=0.89, p=0.003).
conclusionsPre-surgery concentrations of both bone markers were elevated and a significant decrease after PTX was found. Serum βCTX and P1NP levels were potently related to lumbar BMD changes over one year after PTX. The measurement of βCTX and P1NP would be useful to predict long-term changes in lumbar BMD after PTX.
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