Evidence map›Paper›PMID 21945638›Full record

ReviewVirus research2011

Quasispecies as a matter of fact: viruses and beyond.

Samuel Ojosnegros, Celia Perales, Antonio Mas, Esteban Domingo

Open access · greenAbstract readReview
In one paragraph

Review in Virus research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 76 citations in OpenAlex.

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  17. Emergency Services of Viral RNAs: Repair and Remodeling.Microbiology and molecular biology reviews : MMBR · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Samuel OjosnegrosCalifornia Institute of Technology, Division of Biology, 1200 E California Blvd, 91125 Pasadena, CA, USA.
Celia Perales
Antonio Mas
Esteban Domingo
California Institute of Technology · USCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESConsejo Superior de Investigaciones Científicas · ESUniversity of Castilla-La Mancha · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We review the origins of the quasispecies concept and its relevance for RNA virus evolution, viral pathogenesis and antiviral treatment strategies. We emphasize a critical point of quasispecies that refers to genome collectivities as the unit of selection, and establish parallels between RNA viruses and some cellular systems such as bacteria and tumor cells. We refer also to tantalizing new observations that suggest quasispecies behavior in prions, perhaps as a result of the same quantum-mechanical indeterminations that underlie protein conformation and error-prone replication in genetic systems. If substantiated, these observations with prions could lead to new research on the structure-function relationship of non-nucleic acid biological molecules.

Indexed as

Biological EvolutionGenome, ViralAnimalsAntiviral AgentsBacteriaDrug Resistance, ViralHumansMicrobial ConsortiaModels, BiologicalMutationNeoplasmsPrionsProtein ConformationQuantum TheoryRNA VirusesStructure-Activity RelationshipAntiviral AgentsPrions

Identifiers

PMID21945638
PMCPMC7172439
OpenAlexW2056137486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.