Trial reportJournal of biomechanics2011
Paretic muscle atrophy and non-contractile tissue content in individual muscles of the post-stroke lower extremity.
Trial report in Journal of biomechanics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals
Structural Remodeling of the Tibialis Anterior Muscle in Subacute and Chronic Stroke: A Clinical Correlation Study
Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Low body mass index negatively affects muscle mass and intramuscular fat of chronic stroke survivors.PloS one · 2019Trial
- Mechanisms of Post-stroke Stiff-Knee Gait: A Narrative Review.American journal of physical medicine & rehabilitation · 2025Review
- Insights into motor impairment assessment using myographic signals with artificial intelligence: a scoping review.Biomedical engineering letters · 2025Review
- Effect of Ankle-Foot Orthosis on Paretic Gastrocnemius and Tibialis Anterior Muscle Contraction of Stroke Survivors During Walking: A Pilot Study.Biosensors · 2024Article
- The Simultaneous Model-Based Estimation of Joint, Muscle, and Tendon Stiffness is Highly Sensitive to the Tendon Force-Strain Relationship.IEEE transactions on bio-medical engineering · 2024Article
- Immediate Effects of TECAR Therapy on Gastrocnemius and Quadriceps Muscles with Spastic Hypertonia in Chronic Stroke Survivors: A Randomized Controlled Trial.Biomedicines · 2023Article
- Effects of Exercise Training on Muscle Quality in Older Individuals: A Systematic Scoping Review with Meta-Analyses.Sports medicine - open · 2023Article
- Article
- Observational
- Physique, range of motion, and gross muscle strength in hemiplegic para swimmers: a cross-sectional case series.Journal of physical therapy science · 2021Article
- Plantar Pressure and Contact Area Measurement of Foot Abnormalities in Stroke Rehabilitation.Brain sciences · 2021Article
- Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Longer electromechanical delay in paretic triceps surae muscles during voluntary isometric plantarflexion torque generation in chronic hemispheric stroke survivors.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2021Article
- Limited fascicle shortening and fascicle rotation may be associated with impaired voluntary force-generating capacity in pennate muscles of chronic stroke survivors.Clinical biomechanics (Bristol, Avon) · 2020Article
- Effects of Changes in Ankle Joint Angle on the Relation Between Plantarflexion Torque and EMG Magnitude in Major Plantar Flexors of Male Chronic Stroke Survivors.Frontiers in neurology · 2020Article
- Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma.Frontiers in pediatrics · 2020Article
- Intramuscular Fat in the Medial Gastrocnemius Muscle of People Who Have Had a Stroke.Frontiers in bioengineering and biotechnology · 2020Article
- Trailing limb angle is a surrogate for propulsive limb forces during walking post-stroke.Clinical biomechanics (Bristol, Avon) · 2019Article
- Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf.Skeletal radiology · 2018Article
- Muscle Thickness and Echo Intensity of the Abdominal and Lower Extremity Muscles in Stroke Survivors.Journal of clinical neurology (Seoul, Korea) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Muscle atrophy is one of many factors contributing to post-stroke hemiparetic weakness. Since muscle force is a function of muscle size, the amount of muscle atrophy an individual muscle undergoes has implications for its overall force-generating capability post-stroke. In this study, post-stroke atrophy was determined bilaterally in fifteen leg muscles with volumes quantified using magnetic resonance imaging (MRI). All muscle volumes were adjusted to exclude non-contractile tissue content, and muscle atrophy was quantified by comparing the volumes between paretic and non-paretic sides. Non-contractile tissue or intramuscular fat was calculated by determining the amount of tissue excluded from the muscle volume measurement. With the exception of the gracilis, all individual paretic muscles examined had smaller volumes in the non-paretic side. The average decrease in volume for these paretic muscles was 23%. The gracilis volume, on the other hand, was approximately 11% larger on the paretic side. The amount of non-contractile tissue was higher in all paretic muscles except the gracilis, where no difference was observed between sides. To compensate for paretic plantar flexor weakness, one idea might be that use of the paretic gracilis actually causes the muscle to increase in size and not develop intramuscular fat. By eliminating non-contractile tissue from our volume calculations, we have presented volume data that more appropriately represents force-generating muscle tissue. Non-uniform muscle atrophy was observed across muscles and may provide important clues when assessing the effect of muscle atrophy on post-stroke gait.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.