ArticleBiochimica et biophysica acta2011
Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva.
Article in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Salivary gland carbonic anhydrases.Histology and histopathology · 2025Review
- Article
- Murine Salivary Amylase Protects AgainstFrontiers in physiology · 2021Article
- Mineral Trioxide Aggregate Applications in Endodontics: A Review.European journal of dentistry · 2020Article
- Carbonic Anhydrase VI in Skin Wound Healing Study onInternational journal of molecular sciences · 2020Article
- Understanding LrgAB Regulation ofFrontiers in microbiology · 2020Article
- Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse.Physiological genomics · 2018Article
- DLX3-Dependent Regulation of Ion Transporters and Carbonic Anhydrases is Crucial for Enamel Mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.Transgenic research · 2016Article
- Antimicrobial Activity of Peganum Harmala L. on Streptococcus mutans Compared to 0.2% Chlorhexidine.Journal of dentistry (Shiraz, Iran) · 2016Article
- Effectiveness of probiotic, chlorhexidine and fluoride mouthwash against Streptococcus mutans - Randomized, single-blind, in vivo study.Journal of International Society of Preventive & Community Dentistry · 2015Article
- Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva.The Journal of biological chemistry · 2015Article
- Mouthguards: does the indigenous microbiome play a role in maintaining oral health?Frontiers in cellular and infection microbiology · 2015Article
- The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model.Journal of biomedical science · 2014Article
- Human pharyngeal microbiome may play a protective role in respiratory tract infections.Genomics, proteomics & bioinformatics · 2014Article
- Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia.Brain research · 2014Article
- Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans.Biochimica et biophysica acta · 2012Article
- Caries Activity and Ph Level Changes after Fluoride Varnish and Casein Phosphopeptides-Amorphous Calcium Phosphate Application on Children's Saliva.Contemporary clinical dentistryArticle
- Antibacterial effectiveness of probiotic-based experimental mouthwash against cariogenic pathogen: AnEuropean journal of dentistryArticle
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Carbonic anhydrase VI (CA VI), encoded by type A transcripts of the gene Car6, is a secretory product of salivary glands and is found in the enamel pellicle. Because higher caries prevalence is associated with lower salivary concentrations of CA VI in humans, we tested whether CA VI protects enamel surfaces from caries induced by Streptococcus mutans, using Car6(-/-) mice, in which salivary CA VI expression is absent. We detected aberrant Car6 type A transcripts in Car6(-/-) mice, likely targets for nonsense-mediated mRNA decay. Expression of the intracellular stress-induced isoform of CA VI encoded by type B transcripts was restricted to parotid and submandibular glands of wild type mice. The salivary function of Car6(-/-) mice was normal as assessed by the histology and protein/glycoprotein profiles of glands, salivary flow rates and protein/glycoprotein compositions of saliva. Surprisingly, total smooth surface caries and sulcal caries in Car6(-/-) mice were more than 6-fold and 2-fold lower than in wild type mice after infection with S. mutans strain UA159. Recoveries of S. mutans and total microbiota from molars were also lower in Car6(-/-) mice. To explore possible mechanisms for increased caries susceptibility, we found no differences in S. mutans adherence to salivary pellicles, in vitro. Interestingly, higher levels of Lactobacillus murinus and an unidentified Streptococcus species were cultivated from the oral microbiota of Car6(-/-) mice. Collective results suggest salivary CA VI may promote caries by modulating the oral microbiota to favor S. mutans colonization and/or by the enzymatic production of acid within plaque.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.