ArticleSteroids2011
Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies.
Article in Steroids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism.Cell communication and signaling : CCS · 2024Article
- Article
- Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia-Reperfusion Injury in Rats.International journal of molecular sciences · 2022Article
- Response to Letter to the Editor From Behar-Cohen et al.: The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy.The Journal of clinical endocrinology and metabolism · 2022Article
- Gene expression changes in the brain of a Cushing's syndrome mouse model.Journal of neuroendocrinology · 2022Article
- Identification of glucocorticoid receptors as potential modulators of parasympathetic and sympathetic neurons within rat intracardiac ganglia.Frontiers in neuroanatomy · 2022Article
- Identification of Mineralocorticoid Receptors, Aldosterone, and Its Processing Enzyme CYP11B2 on Parasympathetic and Sympathetic Neurons in Rat Intracardiac Ganglia.Frontiers in neuroanatomy · 2021Article
- ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System.Journal of clinical medicine · 2020Review
- Mineralocorticoid receptor antagonists improve membrane integrity independent of muscle force in muscular dystrophy.Human molecular genetics · 2019Article
- The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis.British journal of pharmacology · 2018Article
- Aldosterone Is Essential for Angiotensin II-Induced Upregulation of Pendrin.Journal of the American Society of Nephrology : JASN · 2018Article
- Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.Journal of neuromuscular diseases · 2016Article
- Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Expression of mineralocorticoid and glucocorticoid receptors in preautonomic neurons of the rat paraventricular nucleus.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Mineralocorticoid receptor activation as an etiological factor in kidney diseases.Clinical and experimental nephrology · 2014Review
- RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes.Journal of diabetes research · 2013Article
- The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer.PloS one · 2013Article
- The ubiquitous mineralocorticoid receptor: clinical implications.Current hypertension reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The mineralocorticoid receptor (MR) is a widely distributed ligand activated nuclear transcription factor that is bound by various chaperone proteins that alter its conformation depending upon its location in the cell and whether it is ligand-bound. We describe the development and characterization of new monoclonal antibodies produced against a rat recombinant protein corresponding to aminoacids 5-550 of the MR to produce antibodies that recognize the receptor in specific conformations. Most of the resulting monoclonal antibodies studied were similar to those we produced by immunization with peptide isotopes, however two detected a single band at the appropriate molecular mass as the MR and had distinct immunostaining characteristics in neurons. One labeled cytosolic MR, the other labeled membranes and cytosol, including axons. These antibodies will permit study of the subcellular localization of the MR under various physiological and pathological conditions. We have also confirmed that the MR is highly unstable and requires special handling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.