Evidence map›Paper›PMID 21945393›Full record

ArticleMolecular and cellular neurosciences2012

RETRACTED: Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.

Preeti J Khandelwal, Sonya B Dumanis, Alexander M Herman, G William Rebeck, Charbel E-H Moussa

RetractedErratum issuedOpen access · greenAbstract readRetracted Publication
In one paragraph

Article in Molecular and cellular neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. α-Synuclein modulates tau spreading in mouse brains.The Journal of experimental medicine · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Gene Therapy Models of Alzheimer's Disease and Other Dementias.Methods in molecular biology (Clifton, N.J.) · 2016
    Article
  19. Article
  20. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Preeti J KhandelwalDepartment of Neuroscience, Georgetown University Medical Center. Washington D.C. 20007 USA.
Sonya B DumanisDepartment of Neuroscience, Georgetown University Medical Center. Washington D.C. 20007 USA.
Alexander M HermanDepartment of Biochemistry Molecular and Cell Biology, Georgetown University Medical Center, Washington D.C., 20007 USA.
G William RebeckDepartment of Neuroscience, Georgetown University Medical Center. Washington D.C. 20007 USA.
Charbel E-H MoussaDepartment of Neuroscience, Georgetown University Medical Center. Washington D.C. 20007 USA; Department of Biochemistry Molecular and Cell Biology, Georgetown University Medical Center, Washington D.C., 20007 USA. Electronic address: cem46@georgetown.edu.
Georgetown University · US

Funding

TRANSGENIC MOUSE COREP01AG030128 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REBECK, G WILLIAM · 2009 to 2013
$9.4M
Parkin protection in gene transfer animal models (KO-1 Award)K01AG030378 · NIA · GEORGETOWN UNIVERSITY · PI MOUSSA, CHARBEL · 2008 to 2012
$607k
NIA NIH HHS AG 30378NIA NIH HHS K01 AG030378NIA NIH HHS P01 AG030128
6 · The paper itself

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concerns about the article were raised on PubPeer [https://pubpeer.com/publications/DA4525FDCD8F7FEA2E4ACC9EC9322F] namely that in the western blots there are similarities between Fig. 1D and 1E, Fig. 2B duplicates Fig. 3E, Fig. 4L duplicates Fig. 5A and Fig. 4A partly duplicates Fig. 4F, and Figure 2D is the same as Figure 1B in Algarzae, N., Hebron, M., Miessau, M., Moussa, C.E.H., 2012. Parkin prevents cortical atrophy and Ab-induced alterations of brain metabolism: 13C NMR and magnetic resonance imaging studies in AD models. Neuroscience 225, 22-34. The corresponding author was not able to provide the raw data, and therefore requested to retract the article. Authors Charbel E.-H. Moussa, G. William Rebeck and Alexander M. Herman agreed to this retraction, Preeti J. Khandelwal and Sonya B. Dumanis are no longer in science and could not be contacted.

Indexed as

alpha-SynucleinAnimalsDNA-Binding ProteinsGene Transfer TechniquesGlycogen Synthase Kinase 3InflammationInterleukin-6LentivirusModels, AnimalMotor CortexPhosphorylationRatsRats, Sprague-DawleyTauopathiestau Proteinsalpha-SynucleinDNA-Binding ProteinsGlycogen Synthase Kinase 3Interleukin-6tau Proteins

Identifiers

PMID21945393
PMCPMC3246111
OpenAlexW1969577429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.