ArticleThe Annals of thoracic surgery2011
Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
Article in The Annals of thoracic surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Tricuspid regurgitation in ischemic mitral regurgitation patients: prevalence, predictors for outcome and long-term follow-up.BMC cardiovascular disorders · 2021Article
- Article
- Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.PloS one · 2018Article
- Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall.The Annals of thoracic surgery · 2017Article
- Percutaneous coronary intervention for acute myocardial infarction with mitral regurgitation.Journal of geriatric cardiology : JGC · 2016Article
- Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone.The Annals of thoracic surgery · 2016Article
- Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure.Cardiology research and practice · 2016Review
- Mitral valve disease--morphology and mechanisms.Nature reviews. Cardiology · 2015Review
- Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.The Annals of thoracic surgery · 2014Article
- Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.The Annals of thoracic surgery · 2013Article
- Ischemic mitral regurgitation: not only a bystander.Current cardiology reports · 2012Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChronic ischemic mitral regurgitation (MR) is associated with poor outcome. However, the effect of chronic ischemic MR on left ventricular (LV) remodeling after posterolateral myocardial infarction (MI) remains controversial. We tested the hypothesis that moderate MR accelerates LV remodeling after posterolateral MI.
methodsPosterolateral MI was created in 10 sheep. Cardiac magnetic resonance imaging was performed 2 weeks before and 2, 8, and 16 weeks after MI. Left ventricular and right ventricular volumes were measured, and regurgitant volume was calculated as the difference between LV and right ventricle stroke volumes.
resultsMultivariate mixed effects regression showed that LV volumes at end diastole and end systole and LV sphericity were strongly correlated with both regurgitant volume (p < 0.0001, p = 0.0086, and p = 0.0007, respectively) and percent infarct area (p = 0.0156, p = 0.0307, and p < 0.0001, respectively). Conversely, whereas LV hypertrophy (LV wall volume) increased from 2 weeks to 16 weeks after MI, there was no effect of either regurgitant volume or percent infarct.
conclusionsModerate MR accelerates LV remodeling after posterolateral MI. Further studies are needed to determine whether mitral valve repair is able to slow or reverse MI remodeling after posterolateral MI.
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