ArticleDevelopmental biology2011
Subnuclear development of the zebrafish habenular nuclei requires ER translocon function.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Valproic acid exposure affects social visual lateralization and asymmetric gene expression in zebrafish larvae.Scientific reports · 2024Article
- Targeted knockout of a chemokine-like gene increases anxiety and fear responses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex.Development (Cambridge, England) · 2016Article
- Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus.Neural development · 2014Article
- DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.Molecular biology of the cell · 2014Article
- Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.Genesis (New York, N.Y. : 2000) · 2014Article
- In vivo cell biology in zebrafish - providing insights into vertebrate development and disease.Journal of cell science · 2014Review
- Article
- Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The ventral habenulae of zebrafish develop in prosomere 2 dependent on Tcf7l2 function.Neural development · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The dorsal habenular nuclei (Dh) of the zebrafish are characterized by significant left-right differences in gene expression, anatomy, and connectivity. Notably, the lateral subnucleus of the Dh (LsDh) is larger on the left side of the brain than on the right, while the medial subnucleus (MsDh) is larger on the right compared to the left. A screen for mutations that affect habenular laterality led to the identification of the sec61a-like 1(sec61al1) gene. In sec61al1(c163) mutants, more neurons in the LsDh and fewer in the MsDh develop on both sides of the brain. Generation of neurons in the LsDh occurs more rapidly and continues for a longer time period in mutants than in WT. Expression of Nodal pathway genes on the left side of the embryos is unaffected in mutants, as is the left sided placement of the parapineal organ, which promotes neurogenesis in the LsDh of WT embryos. Ultrastructural analysis of the epithalamus indicates that ventricular precursor cells, which form an epithelium in WT embryos, lose apical-basal polarity in sec61al1(c163) mutants. Our results show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventricular region and differentiate, resulting in formation of bilaterally symmetric habenular nuclei.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.