ReviewCurrent opinion in structural biology2011
Mammalian O-mannosylation: unsolved questions of structure/function.
Review in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.Nature communications · 2022Article
- The Glycoscience of Immunity.Trends in immunology · 2018Review
- Expression in retinal neurons of fukutin and FKRP, the protein products of two dystroglycanopathy-causative genes.Molecular vision · 2018Article
- Biological roles of glycans.Glycobiology · 2017Review
- Article
- A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.PLoS computational biology · 2016Article
- Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans.Chemical communications (Cambridge, England) · 2015Article
- Article
- Mannose metabolism: more than meets the eye.Biochemical and biophysical research communications · 2014Review
- B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan.eLife · 2014Article
- Finding the sweet spot: assembly and glycosylation of the dystrophin-associated glycoprotein complex.Anatomical record (Hoboken, N.J. : 2007) · 2014Review
- Article
- Solving glycosylation disorders: fundamental approaches reveal complicated pathways.American journal of human genetics · 2014Review
- Understanding human glycosylation disorders: biochemistry leads the charge.The Journal of biological chemistry · 2013Review
- The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.The Journal of biological chemistry · 2013Review
- ISPD gene mutations are a common cause of congenital and limb-girdle muscular dystrophies.Brain : a journal of neurology · 2013Article
- Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis.The Journal of biological chemistry · 2012Article
- Two opposing roles of O-glycans in tumor metastasis.Trends in molecular medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Post-translational modification of polypeptides with glycans increases the diversity of the structures of proteins and imparts increased functional diversity. Here, we review the current literature on a relatively new O-glycosylation pathway, the mammalian O-mannosylation pathway. The importance of O-mannosylation is illustrated by the fact that O-mannose glycan structures play roles in a variety of processes including viral entry into cells, metastasis, cell adhesion, and neuronal development. Furthermore, mutations in the enzymes of this pathway are causal for a variety of congenital muscular dystrophies. Here we highlight the protein substrates, glycan structures, and enzymes involved in O-mannosylation as well as our gaps in understanding structure/function relationships in this biosynthetic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.