ReviewBiochimica et biophysica acta2011
Obesity, metabolic dysregulation and oxidative stress in asthma.
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Therapeutic Potential of Arginine-Loaded Red Blood Cell Nanovesicles Targeting Obese Asthma.Mediators of inflammation · 2025Article
- Association between asthma, obesity, and metabolic syndrome in adolescents and young adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- Article
- Basis of preventive and non-pharmacological interventions in asthma.Frontiers in public health · 2023Review
- Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity.Biomolecules · 2022Article
- Relationship between Metabolic Syndrome Components and Severity of Asthma in Outpatients Referring to Alzahra Hospital Clinic.Tanaffos · 2021Article
- Association between Asthma and Type 2 Diabetes Mellitus: Mechanisms and Impact on Asthma Control-A Literature Review.Canadian respiratory journal · 2021Review
- Asthma Phenotypes as a Guide for Current and Future Biologic Therapies.Clinical reviews in allergy & immunology · 2020Review
- Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells.International journal of molecular medicine · 2020Article
- Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies.Journal of cardiovascular and thoracic research · 2020Article
- Diet and Metabolism in the Evolution of Asthma and Obesity.Clinics in chest medicine · 2019Review
- Resveratrol protects against oxidative stress by activating the Keap-1/Nrf2 antioxidant defense system in obese-asthmatic rats.Experimental and therapeutic medicine · 2018Article
- Oxidative status of cardinal ligament in pelvic organ prolapse.Experimental and therapeutic medicine · 2018Article
- Lipid profiles in adolescents with and without asthma: Korea National Health and nutrition examination survey data.Lipids in health and disease · 2018Article
- The relationship between metabolic syndrome and asthma in the elderly.Scientific reports · 2018Article
- Adiponectin in Asthma and Obesity: Protective Agent or Risk Factor for More Severe Disease?Lung · 2015Article
- Asthma and metabolic syndrome: Current knowledge and future perspectives.World journal of clinical cases · 2015Review
- Metabolic syndrome, aging and involvement of oxidative stress.Aging and disease · 2015Review
- Visfatin and ghrelin: can they be forthcoming biomarkers or new drug targets for asthma?International journal of clinical and experimental medicine · 2015Article
- Inflammasome Activity in Non-Microbial Lung Inflammation.Journal of environmental immunology and toxicology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEpidemiological data demonstrate an increased risk of developing incident asthma with increasing adiposity. While the vast majority of studies support the interaction between obesity and asthma, the causality is unclear. SCOPE OF REVIEW: This article will review the current literature supporting the presence of an obese asthma phenotype and the possible mechanisms mediating the effects of obesity on asthma. MAJOR
conclusionsObesity is associated with poor asthma control, altered responsiveness to medications and increased morbidity. Obesity is characterized by systemic inflammation that may result in increased airway inflammation. However, this assertion is not supported by current studies that demonstrate a lack of significant airway inflammation in obese asthmatics. In spite this observation one must consider limitations of these studies including the fact that most subjects were treated with inhaled corticosteroids that would likely alter inflammation in the lung. Thus, it remains unclear if obesity is associated with alterations in inflammation in the airways of subjects with asthma. Hormones such as leptin and adiponectin are affected by obesity and may play a role in mediating innate immune responses and allergic responses, respectively. The role of oxidative stress remains controversial and the current evidence suggests that while oxidative stress is important in asthma, it does not fully explain the characteristics associated with this unique phenotype. GENERAL SIGNIFICANCE: Obesity related asthma is associated with increased morbidity and differential response to asthma therapies. Understanding the mechanisms mediating this phenotype would have significant implications for millions of people suffering with asthma. This article is part of a Special Issue entitled Biochemistry of Asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.