ArticleThe American surgeon2011
Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function.
Article in The American surgeon, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Unplanned postoperative catheterization during admission for coronary artery bypass grafting is neither cheap nor benign, but may rescue patients.The Journal of thoracic and cardiovascular surgery · 2024Article
- Consensus statement-graft treatment in cardiovascular bypass graft surgery.Frontiers in cardiovascular medicine · 2024Article
- A cell permeant phosphopeptide mimetic of Niban inhibits p38 MAPK and restores endothelial function after injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation.Scientific reports · 2017Article
- Adenosine triphosphate as a molecular mediator of the vascular response to injury.The Journal of surgical research · 2017Article
- Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?Annals of vascular diseases · 2017Review
- Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.PloS one · 2017Article
- Traditional graft preparation decreases physiologic responses, diminishes viscoelasticity, and reduces cellular viability of the conduit: A porcine saphenous vein model.Vascular medicine (London, England) · 2016Article
- Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.Journal of vascular surgery · 2016Article
- Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.Journal of vascular surgery · 2016Article
- Surgical marking pen dye inhibits saphenous vein cell proliferation and migration in saphenous vein graft tissue.Journal of vascular surgery · 2016Article
- The Case for Endothelial PreservationFrontiers in surgery · 2016Article
- Standard Surgical Skin Markers Should Be Avoided for Intraoperative Vein Graft Marking during Cardiac and Peripheral Bypass Operations.Frontiers in surgery · 2016Article
- Subfailure Overstretch Injury Leads to Reversible Functional Impairment and Purinergic P2X7 Receptor Activation in Intact Vascular Tissue.Frontiers in bioengineering and biotechnology · 2016Article
- Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function.JAMA surgery · 2014Article
- Arterial shear stress reduces eph-b4 expression in adult human veins.The Yale journal of biology and medicine · 2014Article
- Pressure control during preparation of saphenous veins.JAMA surgery · 2014Article
- Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein.Journal of vascular surgery · 2014Article
- Article
- Intimal thickness associated with endothelial dysfunction in human vein grafts.The Journal of surgical research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Marking human saphenous vein graft (HSV) with a surgical skin marker to prevent twisting on implantation is a common practice in peripheral and coronary artery bypass procedures. This study is designed to examine the effects of surgical skin markers on the HSV smooth muscle and endothelial functional responses. De-identified HSV remnants were collected during peripheral and coronary artery bypass procedures. Physiologic responses of the HSV were measured using a muscle bath. Veins that were marked with surgical skin markers intraoperatively generated significantly less contractile force to depolarizing KCl (110 mM) and receptor-mediated contractile agonists than unmarked HSV, suggesting that surgical skin markers impaired HSV smooth muscle contractility. To directly access the effects of chemical components in the surgical skin markers, unmarked HSV was exposed to isopropyl alcohol (a solvent commonly used in surgical skin markers) or methylene blue (a dye). Smooth muscle contractility was significantly reduced by isopropyl alcohol and methylene blue. Endothelial-dependent relaxation to carbachol was significantly reduced after exposure to surgical skin markers. Our data demonstrated that marking HSV with surgical skin markers reduces smooth muscle and endothelial functional viability.
Indexed as
Identifiers
21944360PMC3957273W1512539898What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.