ReviewCurrent opinion in neurobiology2012
The gain in brain: novel imaging techniques and multiplexed proteomic imaging of brain tissue ultrastructure.
Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.Cell reports · 2020Article
- Super-resolution microscopy for analyzing neuromuscular junctions and synapses.Neuroscience letters · 2020Review
- Q&A: Array tomography.BMC biology · 2018Article
- Characterizing synaptic protein development in human visual cortex enables alignment of synaptic age with rat visual cortex.Frontiers in neural circuits · 2015Article
- Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy.Frontiers in neural circuits · 2014Review
- Systematic, spatial imaging of large multimolecular assemblies and the emerging principles of supramolecular order in biological systems.Journal of molecular recognition : JMR · 2014Review
- Retinal connectomics: towards complete, accurate networks.Progress in retinal and eye research · 2013Review
- Connecting connectomes.Neuroinformatics · 2013Article
- Building retinal connectomes.Current opinion in neurobiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a number of high resolution methods, such as array tomography, stimulated emission depletion microscopy, stochastic optical reconstruction microscopy and automated transmission electron microscopy, which allow a detailed molecular characterization of individual synapses and subsynaptic structures within brain tissues for the first time. While all of these methods still face considerable limitations, a combined complementary approach building on the respective strengths of each method is possible and will enable fascinating research into the proteomic diversity of the nervous system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.