ArticleMethods in enzymology2011
Whole-genome metabolic network reconstruction and constraint-based modeling.
Article in Methods in enzymology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- State-of the-Art Constraint-Based Modeling of Microbial Metabolism: From Basics to Context-Specific Models with a Focus on Methanotrophs.Microorganisms · 2023Review
- Reconstructor: a COBRApy compatible tool for automated genome-scale metabolic network reconstruction with parsimonious flux-based gap-filling.Bioinformatics (Oxford, England) · 2023Article
- Identification of Therapeutic Targets for Medulloblastoma by Tissue-Specific Genome-Scale Metabolic Model.Molecules (Basel, Switzerland) · 2023Article
- Genome-scale models as a vehicle for knowledge transfer from microbial to mammalian cell systems.Computational and structural biotechnology journal · 2023Review
- Comprehensive genome-scale metabolic model of the human pathogenFrontiers in bioinformatics · 2023Article
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- Genome-scale metabolic reconstruction of the symbiosis between a leguminous plant and a nitrogen-fixing bacterium.Nature communications · 2020Article
- Construction, comparison and evolution of networks in life sciences and other disciplines.Journal of the Royal Society, Interface · 2020Article
- Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig.Scientific reports · 2019Article
- Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism.Royal Society open science · 2017Article
- Clostridium butyricum maximizes growth while minimizing enzyme usage and ATP production: metabolic flux distribution of a strain cultured in glycerol.BMC systems biology · 2017Article
- Consistency Analysis of Genome-Scale Models of Bacterial Metabolism: A Metamodel Approach.PloS one · 2015Article
- Big Data Analytics in Healthcare.BioMed research international · 2015Review
- Solving gap metabolites and blocked reactions in genome-scale models: application to the metabolic network of Blattabacterium cuenoti.BMC systems biology · 2013Article
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Archives of toxicology · 2013Review
- Multiscale computational models of complex biological systems.Annual review of biomedical engineering · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
With the advent of modern high-throughput genomics, there is a significant need for genome-scale analysis techniques that can assist in complex systems analysis. Metabolic genome-scale network reconstructions (GENREs) paired with constraint-based modeling are an efficient method to integrate genomics, transcriptomics, and proteomics to conduct organism-specific analysis. This text explains key steps in the GENRE construction process and several methods of constraint-based modeling that can help elucidate basic life processes and development of disease treatment, bioenergy solutions, and industrial bioproduction applications.
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Registered trials
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