ArticleGut pathogens2011
Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses.
Article in Gut pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Selection of Multidrug-Resistant Enterobacteria in Weaned Pigs and Its Association With In-feed Subtherapeutic Combination of Colistin and Tylosin.Current microbiology · 2022Article
- Supplementation of oligosaccharide-based polymer enhanced growth and disease resistance of weaned pigs by modulating intestinal integrity and systemic immunity.Journal of animal science and biotechnology · 2022Article
- Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle.Journal of animal science · 2021Article
- Research Note: Snapshot of the transcriptome via RNA sequencing in the ileum of broiler chickens fed subtherapeutic concentrations of avilamycin.Poultry science · 2021Article
- Effect of fosfomycin,Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Dietary Antibiotic Growth Promoters Down-Regulate Intestinal Inflammatory Cytokine Expression in Chickens Challenged With LPS or Co-infected WithFrontiers in veterinary science · 2019Article
- Article
- Diet supplementation with an organic acids-based formulation affects gut microbiota and expression of gut barrier genes in broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Article
- Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling.Scientific reports · 2018Article
- Optimizing Gastrointestinal Integrity in Poultry: The Role of Nutrients and Feed Additives.Frontiers in veterinary science · 2018Review
- Removal of the cecum affects intestinal fermentation, enteric bacterial community structure, and acute colitis in mice.Gut microbes · 2018Article
- Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota.Scientific reports · 2016Article
- Article
- Anti-microbial Use in Animals: How to Assess the Trade-offs.Zoonoses and public health · 2015Article
- Animal models to study acute and chronic intestinal inflammation in mammals.Gut pathogens · 2015Review
- Article
- Effect of antimicrobial growth promoter administration on the intestinal microbiota of beef cattle.Gut pathogens · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, there is a lack of experimental evidence to support this hypothesis. Using a chlortetracycline-murine-Citrobacter rodentium model, the ability of AGP to modulate the intestinal immune system in mammals was investigated.
resultsC. rodentium was transformed with the tetracycline resistance gene, tetO, and continuous oral administration of a non-therapeutic dose of chlortetracycline to mice did not affect densities of C. rodentium CFU in feces throughout the experiment or associated with mucosal surfaces in the colon (i.e. at peak and late infection). However, chlortetracycline regulated transcription levels of Th1 and Th17 inflammatory cytokines in a temporal manner in C. rodentium-inoculated mice, and ameliorated weight loss associated with infection. In mice inoculated with C. rodentium, those that received chlortetracycline had less pathologic changes in the distal colon than mice not administered CTC (i.e. relative to untreated mice). Furthermore, chlortetracycline administration at a non-therapeutic dose did not impart either prominent or consistent effects on the colonic microbiota.
conclusionData support the hypothesis that AGP function by modulating the intestinal immune system in mammals. This finding may facilitate the development of biorationale-based and efficacious alternatives to AGP.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.