ReviewParasites & vectors2011
Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease.
Review in Parasites & vectors, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- HIV-Helminth Co-Infections and Immune Checkpoints: Implications for Cancer Risk in South Africa.Viruses · 2025Article
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Interaction between Intestinal Parasites and the Gut Microbiota: Implications for the Intestinal Immune Response and Host Defence.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Helminth antigens differentially modulate the activation of CD4BMC medicine · 2022Article
- Intestinal Inflammation and Parkinson's Disease.Aging and disease · 2021Review
- Effects of TLR agonists on immune responses in Trichinella spiralis infected mice.Parasitology research · 2020Article
- Detection of genomic regions underlying resistance to gastrointestinal parasites in Australian sheep.Genetics, selection, evolution : GSE · 2019Article
- Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice.Innate immunity · 2019Article
- The Inhibitory Role of M2000 (β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line.Recent patents on inflammation & allergy drug discovery · 2019Article
- The impact of a helminth-modified microbiome on host immunity.Mucosal immunology · 2018Review
- Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages.Scientific reports · 2018Article
- Current Research of Trichinellosis in China.Frontiers in microbiology · 2017Review
- Schistosoma japonicum HSP60-derived peptide SJMHE1 suppresses delayed-type hypersensitivity in a murine model.Parasites & vectors · 2016Article
- Influence of environmental factors in the development of inflammatory bowel diseases.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Epidemiological and clinical characteristics of inflammatory bowel diseases in Cairo, Egypt.World journal of gastroenterology · 2014Article
- Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice.PloS one · 2014Article
- Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance.Parasites & vectors · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.