ArticleJournal of the American Chemical Society2011
Reporter protein-targeted probes for magnetic resonance imaging.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Click biology highlights the opportunities from reliable biological reactions.Nature chemical biology · 2025Review
- HaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles.Journal of extracellular vesicles · 2024Article
- Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy.Scientific reports · 2023Article
- Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for theMolecules (Basel, Switzerland) · 2022Article
- Anisotropic CdSe Tetrapods in Vortex Flow for Removing Non-Specific Binding and Increasing Protein Capture.Sensors (Basel, Switzerland) · 2022Article
- Recent biomedical advances enabled by HaloTag technology.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2022Article
- Engineering a Metathesis-Catalyzing Artificial Metalloenzyme Based on HaloTag.ACS catalysis · 2021Article
- An Activatable TMolecules (Basel, Switzerland) · 2021Article
- Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.Scientific reports · 2021Article
- Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.Journal of the American Chemical Society · 2019Review
- Enhancing TProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Magnetic barcode imaging for contrast agents.Magnetic resonance in medicine · 2017Article
- Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.Nano letters · 2016Article
- Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.Chemical communications (Cambridge, England) · 2016Article
- Engineering an effective Mn-binding MRI reporter protein by subcellular targeting.Magnetic resonance in medicine · 2015Article
- Article
- Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging.Journal of the American Chemical Society · 2015Article
- HaloTag technology: a versatile platform for biomedical applications.Bioconjugate chemistry · 2015Review
- High relaxivity Gd(III)-DNA gold nanostars: investigation of shape effects on proton relaxation.ACS nano · 2015Article
- Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Contrast agents for magnetic resonance imaging are frequently employed as experimental and clinical probes. Drawbacks include low signal sensitivity, fast clearance, and nonspecificity that limit efficacy in experimental imaging. In order to create a bioresponsive MR contrast agent, a series of four Gd(III) complexes targeted to the HaloTag reporter were designed and synthesized. HaloTag is unique among reporter proteins for its specificity, versatility, and the covalent interaction between substrate and protein. In similar systems, these properties produce prolonged in vivo lifetimes and extended imaging opportunities for contrast agents, longer rotational correlation times, and increases in relaxivity (r(1)) upon binding to the HaloTag protein. In this work we report a new MR contrast probe, 2CHTGd, which forms a covalent bond with its target protein and results in a dramatic increase in sensitivity. A 6-fold increase in r(1), from 3.8 to 22 mM(-1) s(-1), is observed upon 2CHTGd binding to the target protein. This probe was designed for use with the HaloTag protein system which allows for a variety of substrates (specific for MRI, florescence, or protein purification applications) to be used with the same reporter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.