ArticleAntioxidants & redox signaling2012
Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Article in Antioxidants & redox signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Immunization with Mycobacterium vaccae attenuates age-associated transcriptional remodeling and microglial reactivity in the rat hippocampus.Journal of neuroimmunology · 2026Article
- Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson's Disease.Neurology international · 2024Review
- Senescent neurophysiology: CaNeurobiology of learning and memory · 2019Review
- Article
- Redox Signaling in Neurotransmission and Cognition During Aging.Antioxidants & redox signaling · 2018Review
- Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.Frontiers in molecular neuroscience · 2017Article
- Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.Molecular medicine reports · 2016Article
- Re-Opening the Critical Window for Estrogen Therapy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence.Neurobiology of learning and memory · 2015Article
- Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats.Neurobiology of aging · 2014Article
- The synthetic thyroid hormone, levothyroxine, protects cholinergic neurons in the hippocampus of naturally aged mice.Neural regeneration research · 2014Article
- Roles for NF-κB and gene targets of NF-κB in synaptic plasticity, memory, and navigation.Molecular neurobiology · 2014Review
- Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.Neurobiology of aging · 2014Article
- Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A high-salt diet further impairs age-associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway rats.The Journal of nutrition · 2013Article
- Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria.Journal of neurochemistry · 2013Article
- Role of estrogen receptor α and β in preserving hippocampal function during aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Insights into CNS ageing from animal models of senescence.Nature reviews. Neuroscience · 2012Review
- A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
aimsStudies employing transgenic mice indicate that overexpression of superoxide dismutase 1 (SOD1) improves memory during aging. It is unclear whether the improvement is due to a lifetime of overexpression, decreasing the accumulation of oxidized molecules, or if increasing antioxidant enzymes in older animals could reduce oxidative damage and improve cognitive function. We used adeno-associated virus to deliver antioxidant enzymes (SOD1, SOD2, catalase [CAT], and SOD1+CAT) to the hippocampus of young (4 months) and aged (19 months) F344/BN F1 male rats and examined memory-related behavioral performance 1 month and 4 months postinjection.
resultsOverexpression of antioxidant enzymes reduced oxidative damage; however, memory function was not related to the level of oxidative damage. Increased expression of SOD1, initiated in advanced age, impaired learning. Increased expression of SOD1+CAT provided protection from impairments associated with overexpression of SOD1 alone and appears to guard against cognitive impairments in advanced age. INNOVATION: Viral vector gene delivery provides a novel approach to test the hypothesis that increased expression of antioxidant enzymes, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. Further, expression of multiple vectors permits more detailed investigation of mechanistic pathways.
conclusionOxidative stress is a likely component of aging; however, it is unclear whether increased production of reactive oxygen species or the accumulation of oxidative damage is the primary cause of functional decline. The results provide support for the idea that altered redox-sensitive signaling rather than the accumulation of damage may be of greater significance in the emergence of age-related learning and memory deficits.
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