ArticleHepatitis research and treatment2011
Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia.
Article in Hepatitis research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study.Advances in virology · 2024Article
- Characterization of patients with acutely decompensated cirrhosis who received care in different highly complex emergency services of Medellín, Colombia.Biomedica : revista del Instituto Nacional de Salud · 2023Observational
- Epidemiology and Genetic Diversity of Hepatitis B Virus and Hepatitis Delta Virus Infection in Indigenous Communities in Colombia.Microorganisms · 2023Article
- [Epidemiology of hepatitis C virus infection in ColombiaEpidemiologia da infecção pelo vírus da hepatite C na Colômbia].Revista panamericana de salud publica = Pan American journal of public health · 2021Article
- Molecular characterization of occult hepatitis B virus infection in patients with end-stage liver disease in Colombia.PloS one · 2017Article
- Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.PloS one · 2017Article
- Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia.Virology journal · 2015Article
- Occult hepatitis B virus infection among blood donors in Colombia.Virology journal · 2014Article
- Hepatitis B virus infection in Latin America: a genomic medicine approach.World journal of gastroenterology · 2014Review
- Comparative analysis of CpG islands among HBV genotypes.PloS one · 2013Article
- Molecular characterization of hepatitis c virus in multi-transfused Colombian patients.Virology journal · 2012Article
- Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia.Hepatitis research and treatment · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5' UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption.
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Registered trials
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