ArticleObstetrics and gynecology international2012
Pelvic organ distribution of mesenchymal stem cells injected intravenously after simulated childbirth injury in female rats.
Article in Obstetrics and gynecology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Long-term effects of muscle-derived stem cell therapy on the regeneration of the urethra of female rats.International urogynecology journal · 2022Article
- Regenerative medicine for anal incontinence: a review of regenerative therapies beyond cells.International urogynecology journal · 2021Review
- Regenerative Medicine Approaches in Bioengineering Female Reproductive Tissues.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- MSC-based therapy in female pelvic floor disorders.Cell & bioscience · 2020Review
- Regenerative potential of human dental pulp stem cells in the treatment of stress urinary incontinence: In vitro and in vivo study.Cell proliferation · 2019Article
- Multiple doses of stem cells maintain urethral function in a model of neuromuscular injury resulting in stress urinary incontinence.American journal of physiology. Renal physiology · 2019Article
- Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy.Journal of anatomy · 2019Article
- Systemically transplanted mesenchymal stem cells induce vascular-like structure formation in a rat model of vaginal injury.PloS one · 2019Article
- Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemiaAmerican journal of translational research · 2019Article
- rHGF interacts with rIGF-1 to activate the satellite cells in the striated urethral sphincter in rats: a promising treatment for urinary incontinence?Archives of gynecology and obstetrics · 2018Article
- Fate of mesoangioblasts in a vaginal birth injury model: influence of the route of administration.Scientific reports · 2018Article
- Review
- Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model.Stem cells translational medicine · 2018Article
- Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall.Menopause (New York, N.Y.) · 2017Article
- Cell-based secondary prevention of childbirth-induced pelvic floor trauma.Nature reviews. Urology · 2017Review
- Local versus intravenous injections of skeletal muscle precursor cells in nonhuman primates with acute or chronic intrinsic urinary sphincter deficiency.Stem cell research & therapy · 2016Article
- In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.International journal of molecular medicine · 2016Article
- Bone marrow mesenchymal stem cell therapy for voiding dysfunction.Current urology reports · 2015Review
- The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency.Stem cells translational medicine · 2015Article
- Stem cells as drug delivery methods: application of stem cell secretome for regeneration.Advanced drug delivery reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The local route of stem cell administration utilized presently in clinical trials for stress incontinence may not take full advantage of the capabilities of these cells. The goal of this study was to evaluate if intravenously injected mesenchymal stem cells (MSCs) home to pelvic organs after simulated childbirth injury in a rat model. Female rats underwent either vaginal distension (VD) or sham VD. All rats received 2 million GFP-labeled MSCs intravenously 1 hour after injury. Four or 10 days later pelvic organs and muscles were imaged for visualization of GFP-positive cells. Significantly more MSCs home to the urethra, vagina, rectum, and levator ani muscle 4 days after VD than after sham VD. MSCs were present 10 days after injection but GFP intensity had decreased. This study provides basic science evidence that intravenous administration of MSCs could provide an effective route for cell-based therapy to facilitate repair after injury and treat stress incontinence.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.