ArticleJournal of toxicology2011
Lead-binding proteins: a review.
Article in Journal of toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 86 citations in OpenAlex.
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- Heat-Induced Changes in Avian (Cortical and Medullary) Bone Mineral Reactivity, Solubility, and Adsorption Capacity.ACS omega · 2026Article
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Metal-Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations.Proteins · 2026Article
- Exploring biochemical considerations for diffusive alpha radiation therapy (DaRT) models.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025Review
- DRGD-linked charged EKKE dimeric dodecapeptide: pH-based amyloid nanostructures and their application in lead and uranium binding.RSC advances · 2024Article
- Multi-Element Profile Characterization of Monofloral and Polyfloral Honey from Latvia.Foods (Basel, Switzerland) · 2023Article
- Correspondence on "Endocytosis-Mediated Transport of Pb in Rat Blood Cells".Environmental science & technology · 2023Article
- Parkinson's Disease and the Metal-Microbiome-Gut-Brain Axis: A Systems Toxicology Approach.Antioxidants (Basel, Switzerland) · 2021Review
- Changes in Copper, Zinc, Arsenic, Mercury, and Lead Concentrations in Rat Biofluids and Tissues Induced by the "Renqing Changjue" Pill, a Traditional Tibetan Medicine.Biological trace element research · 2021Article
- Toxic Metal Species and 'Endogenous' Metalloproteins at the Blood-Organ Interface: Analytical and Bioinorganic Aspects.Molecules (Basel, Switzerland) · 2021Article
- Biomonitoring of Lead Exposure in Children from Two Fishing Communities at Northern Colombia.Biological trace element research · 2021Article
- Soft-Templating of Sulfur and Iron Dual-Doped Mesoporous Carbons: Lead Adsorption in Mixtures.Molecules (Basel, Switzerland) · 2020Article
- Infrared and 2-Dimensional Correlation Spectroscopy Study of the Effect of CHMolecules (Basel, Switzerland) · 2020Article
- Toxicodynamics of Lead, Cadmium, Mercury and Arsenic- induced kidney toxicity and treatment strategy: A mini review.Toxicology reports · 2018Review
- Environmental toxin-induced acute kidney injury.Clinical kidney journal · 2017Review
- Mammalian Metallothionein-3: New Functional and Structural Insights.International journal of molecular sciences · 2017Review
- Lead(II) Binding in Natural and Artificial Proteins.Metal ions in life sciences · 2017Article
- Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice.Journal of applied toxicology : JAT · 2015Article
- Arsenic and manganese alter lead deposition in the rat.Biological trace element research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead-binding proteins are a series of low molecular weight proteins, analogous to metallothionein, which segregate lead in a nontoxic form in several organs (kidney, brain, lung, liver, erythrocyte). Whether the lead-binding proteins in every organ are identical or different remains to be determined. In the erythrocyte, delta-aminolevulinic acid dehydratase (ALAD) isoforms have commanded the greatest attention as proteins and enzymes that are both inhibitable and inducible by lead. ALAD-2, although it binds lead to a greater degree than ALAD-1, appears to bind lead in a less toxic form. What may be of greater significance is that a low molecular weight lead-binding protein, approximately 10 kDa, appears in the erythrocyte once blood lead exceeds 39 μg/dL and eventually surpasses the lead-binding capacity of ALAD. In brain and kidney of environmentally exposed humans and animals, a cytoplasmic lead-binding protein has been identified as thymosin β4, a 5 kDa protein. In kidney, but not brain, another lead-binding protein has been identified as acyl-CoA binding protein, a 9 kDa protein. Each of these proteins, when coincubated with liver ALAD and titrated with lead, diminishes the inhibition of ALAD by lead, verifying their ability to segregate lead in a nontoxic form.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.