ArticleFrontiers in pharmacology2011
Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.
Article in Frontiers in pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 80 citations in OpenAlex.
- Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Trial
- Molecular Insight into the Role of Vitamin D in Immune-Mediated Inflammatory Diseases.International journal of molecular sciences · 2025Review
- Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia.Nutrients · 2023Review
- Review
- Common genetic aspects between COVID-19 and sarcoidosis: A network-based approach using gene expression data.Biochemistry and biophysics reports · 2022Article
- Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD.The clinical respiratory journal · 2021Article
- Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels.The Journal of steroid biochemistry and molecular biology · 2021Article
- Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease?Current nutrition reports · 2020Review
- Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement.Arquivos brasileiros de oftalmologia · 2020Article
- In sickness and in health: pivotal role of vitamin D.Biochemia medica · 2020Review
- Lipid-Rich Extract from Mexican Avocado Seed (Journal of immunology research · 2019Article
- Early-Life Persistent Vitamin D Deficiency Alters Cardiopulmonary Responses to Particulate Matter-Enhanced Atmospheric Smog in Adult Mice.Environmental science & technology · 2018Article
- Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.Tissue barriers · 2018Article
- Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.The Journal of physiology · 2017Review
- Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice.Scientific reports · 2017Observational
- Vitamin D Supplementation for Patients with Dry Eye Syndrome Refractory to Conventional Treatment.Scientific reports · 2016Observational
- Assessing Early Life Factors for Eosinophilic Esophagitis: Lessons From Other Allergic Diseases.Current treatment options in gastroenterology · 2016Article
- Benefits from the correction of vitamin D deficiency in patients with pulmonary hypertension.Caspian journal of internal medicine · 2016Article
- Relation between Vitamin D Deficiency and Severity of Chronic Obstructive Pulmonary Disease-A Case Control Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Asthma.Nature reviews. Disease primers · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environmental agents (airborne particulates). Recent studies have highlighted the role of vitamin D and vitamin D receptor (VDR) in regulation of several genes that are involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis. Vitamin D has also been implicated in reversal of steroid resistance and airway remodeling, which are the hallmarks of chronic obstructive pulmonary disease (COPD) and severe asthma. VDR protein level is decreased in lungs of patients with COPD. VDR deficient mice develop an abnormal lung phenotype with characteristics of COPD, such as airspace enlargement and decline in lung function associated with increased lung inflammatory cellular influx, and immune-lymphoid aggregates formation. Dietary vitamin D may regulate epigenetic events, in particular on genes which are responsible for COPD susceptibility. Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism. This review provides an update on the current knowledge and understanding on vitamin D, and susceptibility of chronic lung diseases in relation to the possible role of epigenetics in its molecular action. Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.