ArticleTherapeutics and clinical risk management2011
The effect of a physician-targeted intervention on metoclopramide prescribing practice.
Article in Therapeutics and clinical risk management, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- High exposure compared with standard exposure to metoclopramide associated with a higher risk of parkinsonism: a nationwide population-based cohort study.British journal of clinical pharmacology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetoclopramide use is associated with serious and potentially irreversible neurologic side effects. However, it is often used for questionable or unclear indications in clinical practice.
objectivesTo (1) determine whether an intervention targeted at the prescribing physician would increase the rate of metoclopramide discontinuation among patients prescribed the medication for questionable or unclear indications; and (2) assess the durability of the discontinuation. STUDY
designA randomized controlled trial.
settingAmbulatory practices of a quaternary care medical center.
participantsAmbulatory, electronic medical record-utilizing clinicians of the quaternary medical center.
interventionA letter regarding participating clinicians' prescription(s) of metoclopramide for patients with questionable or unclear indications.
main outcome measuresThe rate and the durability of metoclopramide discontinuation.
resultsFourteen of 31 (45%) patients of intervention group clinicians and 10 of 30 (33%) patients of nonintervention group clinicians had metoclopramide discontinued within 12 weeks, yielding a risk ratio for metoclopramide discontinuation of 1.4 (95% confidence interval [CI] 0.6-3.0) in the intervention versus nonintervention group. Of the 29 patients who had their metoclopramide discontinued during the study, 26 (90%, 95% CI 73%-98%) still had no active metoclopramide prescription in the subsequent 6 months. No adverse events were detected during the follow-up period.
conclusionA physician-targeted intervention letter did not lead to a statistically significantly increased rate of metoclopramide discontinuation among patients who had questionable or unclear indications for the medication. Discontinuation of metoclopramide therapy for questionable or unclear indications was durable in most patients.
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