Evidence map›Paper›PMID 21941366›Full record

ArticleLeukemia2012

Proliferation centers in chronic lymphocytic leukemia: correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays.

M Ciccone, C Agostinelli, G M Rigolin, P P Piccaluga, F Cavazzini, S Righi, M T Sista, O Sofritti, L Rizzotto, E Sabattini and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Article
  16. Chronic lymphocytic leukemia with TP53 gene alterations: a detailed clinicopathologic analysis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020
    Article
  17. Current trends in the management of Richter's syndrome.International journal of hematologic oncology · 2018
    Review
  18. Review
  19. TP53 Staining in Tissue Samples of Chronic Lymphocytic Lymphoma Cases: An Immunohistochemical Survey of 51 Cases.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

M CicconeDepartment of Biomedical Sciences, Hematology Section, S.Anna Hospital, University of Ferrara, Ferrara, Italy.
C Agostinelli
G M Rigolin
P P Piccaluga
F Cavazzini
S Righi
M T Sista
O Sofritti
L Rizzotto
E Sabattini
G Fioritoni
S Falorio
C Stelitano
A Olivieri
I Attolico
M Brugiatelli
P L Zinzani
E Saccenti
D Capello
M Negrini
A Cuneo
S Pileri

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To better define the significance of proliferation centers (PCs), the morphological hallmark of chronic lymphocytic leukemia (CLL), lymph node biopsies taken from 183 patients were submitted to histopathologic and fluorescence in situ hybridization (FISH) studies using a 5-probe panel on tissue microarrays. Seventy-five cases (40.9%) with confluent PCs were classified as 'PCs-rich' and 108 cases (59.1%) with scattered PCs were classified as 'typical'. Complete FISH data were obtained in 101 cases (55.1%), 79 of which (78.2%) displayed at least one chromosomal aberration. The incidence of each aberration was: 13q- 36,7%, 14q32 translocations 30.8%, 11q- 24.7%, trisomy 12 19.5% and 17p- 15.6%. Five cases showed extra copies of the 14q32 region. The 'PCs-rich' group was associated with 17p-, 14q32/IgH translocation, +12, Ki-67>30%. The median survival from the time of tissue biopsy for PCs-rich and typical groups was 11 and 64 months, respectively (P=0.00001). The PCs-rich pattern was the only predictive factor of an inferior survival at multivariate analysis (P=0.022). These findings establish an association between cytogenetic profile and the amount of PC in CLL, and show that this histopathologic characteristic is of value for risk assessment in patients with clinically significant adenopathy.

Indexed as

Chromosome AberrationsTissue Array AnalysisFemaleHumansImmunoglobulin Heavy ChainsIn Situ Hybridization, FluorescenceLeukemia, Lymphocytic, Chronic, B-CellMaleMutationPrognosisRisk FactorsImmunoglobulin Heavy Chains

Identifiers

PMID21941366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.