Evidence map›Paper›PMID 21941283›Full record

GuidelineNature reviews. Cancer2011

Rethinking ovarian cancer: recommendations for improving outcomes.

Sebastian Vaughan, Jermaine I Coward, Robert C Bast, Andy Berchuck, Jonathan S Berek, James D Brenton, George Coukos, Christopher C Crum, Ronny Drapkin, Dariush Etemadmoghadam and 16 more

2 registry-linked trialsAbstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in Nature reviews. Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 728 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
728citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03188159 phase2unknown statusnot on this mapstarted 2017, after this paper: background citation

Phase II Study of Intravenous Vinorelbine in Patients With Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer (VIP)

TypeinterventionalSponsorNational University Hospital, SingaporeRan2017 to 2022Enrolled36ConditionsOvarian Cancer, Fallopian Tube CancerArmsVinorelbine
NCT03467178 phase2unknown statusnot on this mapstarted 2018, after this paper: background citation

Randomized Phase II Study on Decitabine Plus Carboplatin Versus Physician's Choice Chemotherapy in Recurrent, Platinum-resistant Ovarian Cancer.

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2018 to 2021Enrolled119ConditionsRecurrent, Platinum-resistant Ovarian CancerArmsDecitabine, Carboplatin, Pegylated Liposomal Doxorubicin, Gemcitabine, Paclitaxel
3 · Its place in the literature

Who cites it

728 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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668 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sebastian VaughanOvarian Cancer Action Research Centre, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Jermaine I Coward
Robert C Bast
Andy Berchuck
Jonathan S Berek
James D Brenton
George Coukos
Christopher C Crum
Ronny Drapkin
Dariush Etemadmoghadam
Michael Friedlander
Hani Gabra
Stan B Kaye
Chris J Lord
Ernst Lengyel
Douglas A Levine
Iain A McNeish
Usha Menon
Gordon B Mills
Kenneth P Nephew
Amit M Oza
Anil K Sood
Euan A Stronach
Henning Walczak
David D Bowtell
Frances R Balkwill

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BODURKA, DIANE · 2003 to 2020
$32.0M
Novel Serum, Plasma, and Urine Biomarkers of Ovarian CanP50CA105009 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 2004 to 2010
$13.3M
Texas Center for Cancer NanomedicineU54CA151668 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2010 to 2014
$12.4M
Proteomic, Genomic, and Longitudinal Pathways to Ovarian Cancer Biomarker DiscoveryU01CA152990 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BIRRER, MICHAEL, SKATES, STEVEN J · 2010 to 2021
$8.9M
Ovarian Cancer: Mechanisms of Neuroendocrine RegulationR01CA109298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2005 to 2017
$4.5M
Subcellular localization of nanoparticlesRC2GM092599 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHIU, WAH, DECUZZI, PAOLO · 2009 to 2010
$3.0M
Regulation of Adhesion and Proteolysis in Ovarian CancerR01CA111882 · NCI · UNIVERSITY OF CHICAGO · PI LENGYEL, ERNST · 2006 to 2016
$2.8M
DNA Methylation and Ovarian CancerR01CA085289 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NEPHEW, KENNETH P · 2002 to 2012
$2.4M
Tumor Targeted Nanobins for the Treatment of Metastatic Breast and Ovarian CancerU01CA151461 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V · 2010 to 2014
$2.2M
Cancer Research UK 15601Medical Research Council G0501974Medical Research Council G0601891NCI NIH HHS CA109298NCI NIH HHS CA85289NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA083639NCI NIH HHS P50 CA098258NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA83639NCI NIH HHS R01 CA085289NCI NIH HHS R01 CA111882NCI NIH HHS U01 CA151461NCI NIH HHS U01 CA152990NCI NIH HHS U54 CA151668NIGMS NIH HHS RC2GM092599
6 · The paper itself

Abstract

There have been major advances in our understanding of the cellular and molecular biology of the human malignancies that are collectively referred to as ovarian cancer. At a recent Helene Harris Memorial Trust meeting, an international group of researchers considered actions that should be taken to improve the outcome for women with ovarian cancer. Nine major recommendations are outlined in this Opinion article.

Indexed as

Ovarian NeoplasmsAnimalsAntineoplastic AgentsClinical Trials as TopicFemaleHealth Planning GuidelinesHumansTreatment OutcomeAntineoplastic Agents

Identifiers

PMID21941283
PMCPMC3380637

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.