ReviewRNA biology
Alternative splicing at the right time.
Review in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Alternative splicing-mediated regulation of a novel allele of Badh2 drives moderate accumulation of 2-AP in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The mRNA puzzle: Intron retention under stress.The Plant cell · 2024Article
- Fine-Tuning of the Grain Size by Alternative Splicing of GS3 in Rice.Rice (New York, N.Y.) · 2022Article
- Article
- Many Facets of Dynamic Plasticity in Plants.Cold Spring Harbor perspectives in biology · 2019Review
- 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System.Plant physiology · 2018Article
- Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.Molecular neurobiology · 2018Review
- Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.Scientific reports · 2017Article
- Protein Sam68 regulates the alternative splicing of survivin DEx3.The Journal of biological chemistry · 2017Article
- Intron retention and rhythmic diel pattern regulation of carotenoid cleavage dioxygenase 2 during crocetin biosynthesis in saffron.Plant molecular biology · 2016Article
- RNA around the clock - regulation at the RNA level in biological timing.Frontiers in plant science · 2015Review
- Genes with a large intronic burden show greater evolutionary conservation on the protein level.BMC evolutionary biology · 2014Article
- Multiple layers of posttranslational regulation refine circadian clock activity in Arabidopsis.The Plant cell · 2014Review
- Regulation of alternative splicing by local histone modifications: potential roles for RNA-guided mechanisms.Nucleic acids research · 2014Review
- On the physiological significance of alternative splicing events in higher plants.Protoplasma · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as well as through epigenetic modifications. However, to what extent these different mechanisms contribute to the regulation of AS in response to endogenous or environmental stimuli is still unclear. Circadian clocks allow organisms to adjust physiological processes to daily changes in environmental conditions. Here we review recent evidence linking circadian clock and AS, and discuss the role of Protein Arginine Methyltransferase 5 (PRMT5) in these processes. We propose that the interactions between daily oscillations in AS and circadian rhythms in the expression of splicing factors and epigenetic regulators offer a great opportunity to dissect the contribution of these mechanisms to the regulation of AS in a physiologically relevant context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.