ArticleRNA biology
Transcriptional activators enhance polyadenylation of mRNA precursors.
Article in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- CPEB2 Is Necessary for Proper Porcine Meiotic Maturation and Embryonic Development.International journal of molecular sciences · 2018Article
- Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q.Human genomics · 2017Article
- Epitope-tagged yeast strains reveal promoter driven changes to 3'-end formation and convergent antisense-transcription from common 3' UTRs.Nucleic acids research · 2016Article
- Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Noncoding RNA and its associated proteins as regulatory elements of the immune system.Nature immunology · 2014Review
- Implications of polyadenylation in health and disease.Nucleus (Austin, Tex.) · 2014Review
- The RNA polymerase II CTD coordinates transcription and RNA processing.Genes & development · 2012Review
- Specificity factors in cytoplasmic polyadenylation.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3' processing of mRNA precursors is frequently coupled to transcription by RNA polymerase II (RNAP II). This coupling is well known to involve the C-terminal domain of the RNAP II largest subunit, but a variety of other transcription-associated factors have also been suggested to mediate coupling. Our recent studies have provided direct evidence that transcriptional activators can enhance the efficiency of transcription-coupled 3' processing. In this point-of-view, we discuss the mechanisms that underlie coupling, and their implications for control of alternative polyadenylation, which is emerging as a significant regulator of cell growth control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.